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Wick, Antje [Author]; Desjardins, Annick [Author]; Suárez García, Cristina [Author]; Forsyth, Peter [Author]; Gueorguieva, Ivelina [Author]; Burkholder, Tiana [Author]; Cleverly, Ann Louise [Author]; Estrem, Shawn T. [Author]; Wang, Shuaicheng [Author]; Lahn, Michael M. [Author]; Guba, Susan C. [Author]; Capper, David [Author]; Rodon, Jordi [Author]

Phase 1b/2a study of galunisertib, a small molecule inhibitor of transforming growth factor-beta receptor I, in combination with standard temozolomide-based radiochemotherapy in patients with newly diagnosed malignant glioma

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05 March 2020

Published in: Investigational new drugs ; 38(2020), 5, Seite 1570-1579
Gueorguieva, Ivelina; Rowland, Malcolm

A Comment on the “Correction” of Tissue–Plasma Partition Coefficients for Drug Extraction in Eliminating Organs by Sven Björkman

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Springer Science and Business Media LLC, 2005

Published in: Journal of Pharmacokinetics and Pharmacodynamics
Yuen, Eunice; Gueorguieva, Ivelina; Aarons, Leon

Handling Missing Data in a Duloxetine Population Pharmacokinetic/Pharmacodynamic Model – Imputation Methods and Selection Models

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Springer Science and Business Media LLC, 2014

Published in: Pharmaceutical Research
Klein, Kerenaftali; Gueorguieva, Ivelina; Aarons, Leon

Population pharmacokinetic modelling of S-warfarin to evaluate the design of drug–drug interaction studies for CYP2C9

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Springer Science and Business Media LLC, 2012

Published in: Journal of Pharmacokinetics and Pharmacodynamics
Gueorguieva, Ivelina; Aarons, Leon; Rowland, Malcolm

Diazepam Pharamacokinetics from Preclinical to Phase I Using a Bayesian Population Physiologically Based Pharmacokinetic Model with Informative Prior Distributions in Winbugs

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Springer Science and Business Media LLC, 2006

Published in: Journal of Pharmacokinetics and Pharmacodynamics
Gueorguieva, Ivelina; Nestorov, Ivan A.; Rowland, Malcolm

Reducing Whole Body Physiologically Based Pharmacokinetic Models Using Global Sensitivity Analysis: Diazepam Case Study

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Springer Science and Business Media LLC, 2006

Published in: Journal of Pharmacokinetics and Pharmacodynamics
Graham, Gordon; Gueorguieva, Ivelina; Dickens, Kelly

A program for the optimum design of pharmacokinetic, pharmacodynamic, drug metabolism and drug–drug interaction models

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Elsevier BV, 2005

Published in: Computer Methods and Programs in Biomedicine
Zecchin, Chiara; Gueorguieva, Ivelina; Enas, Nathan H.; Friberg, Lena E.

Models for change in tumour size, appearance of new lesions and survival probability in patients with advanced epithelial ovarian cancer

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Wiley, 2016

Published in: British Journal of Clinical Pharmacology
Yuen, Eunice; Gueorguieva, Ivelina; Wise, Stephen; Soon, Danny; Aarons, Leon

Ethnic differences in the population pharmacokinetics and pharmacodynamics of warfarin

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Springer Science and Business Media LLC, 2010

Published in: Journal of Pharmacokinetics and Pharmacodynamics
Ogungbenro, Kayode; Graham, Gordon; Gueorguieva, Ivelina; Aarons, Leon

Incorporating Correlation in Interindividual Variability for the Optimal Design of Multiresponse Pharmacokinetic Experiments

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Informa UK Limited, 2008

Published in: Journal of Biopharmaceutical Statistics
Langdon, Grant; Gueorguieva, Ivelina; Aarons, Leon; Karlsson, Mats

Linking preclinical and clinical whole-body physiologically based pharmacokinetic models with prior distributions in NONMEM

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Springer Science and Business Media LLC, 2007

Published in: European Journal of Clinical Pharmacology
Ogungbenro, Kayode; Gueorguieva, Ivelina; Majid, Oneeb; Graham, Gordon; Aarons, Leon

Optimal Design for Multiresponse Pharmacokinetic–Pharmacodynamic Models – Dealing with Unbalanced Designs

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Springer Science and Business Media LLC, 2007

Published in: Journal of Pharmacokinetics and Pharmacodynamics
Gueorguieva, Ivelina; Ogungbenro, Kayode; Graham, Gordon; Glatt, Sophie; Aarons, Leon

A program for individual and population optimal design for univariate and multivariate response pharmacokinetic–pharmacodynamic models

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Elsevier BV, 2007

Published in: Computer Methods and Programs in Biomedicine
Gueorguieva, Ivelina; Nestorov, Ivan A.; Aarons, Leon; Rowland, Malcolm

Uncertainty Analysis in Pharmacokinetics and Pharmacodynamics: Application to Naratriptan

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Springer Science and Business Media LLC, 2005

Published in: Pharmaceutical Research
Ogungbenro, Kayode; Graham, Gordon; Gueorguieva, Ivelina; Aarons, Leon

The use of a modified Fedorov exchange algorithm to optimise sampling times for population pharmacokinetic experiments

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Elsevier BV, 2005

Published in: Computer Methods and Programs in Biomedicine
Gueorguieva, Ivelina I.; Nestorov, Ivan A.; Rowland, Malcolm

Fuzzy Simulation of Pharmacokinetic Models: Case Study of Whole Body Physiologically Based Model of Diazepam

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Springer Science and Business Media LLC, 2004

Published in: Journal of Pharmacokinetics and Pharmacodynamics
Cassidy, Kenneth C.; Gueorguieva, Ivelina; Miles, Colin; Rehmel, Jessica; Yi, Ping; Ehlhardt, William J.

Disposition and metabolism of [14C]-galunisertib, a TGF-βRI kinase/ALK5 inhibitor, following oral administration in healthy subjects and mechanistic prediction of the effect of itraconazole on galunisertib pharmacokinetics

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Informa UK Limited, 2018

Published in: Xenobiotica
Ding, Xuan; Gueorguieva, Ivelina; Wesley, James A.; Burns, Lee J.; Coutant, Carrie A.

Assessment of In Vivo Clinical Product Performance of a Weak Basic Drug by Integration of In Vitro Dissolution Tests and Physiologically Based Absorption Modeling

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Springer Science and Business Media LLC, 2015

Published in: The AAPS Journal
Polster, Christopher S.; Wu, Sy-Juen; Gueorguieva, Ivelina; Sperry, David C.

Mechanism for Enhanced Absorption of a Solid Dispersion Formulation of LY2300559 Using the Artificial Stomach Duodenum Model

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American Chemical Society (ACS), 2015

Published in: Molecular Pharmaceutics
Gueorguieva, Ivelina; Jackson, Kimberley; Wrighton, Steven A.; Sinha, Vikram P.; Chien, Jenny Y.

Desipramine, substrate for CYP2D6 activity: population pharmacokinetic model and design elements of drug–drug interaction trials

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Wiley, 2010

Published in: British Journal of Clinical Pharmacology

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