> Details

Weide, Rudolf; Schnell, Roland; Schardt, Christof; Koenigsmann, Michael; Otremba, Burkhard; Zahn, Mark-Oliver; Wierecky, Jan; Braun, Ute; Hensel, Manfred; Klausmann, Martine; Fleckenstein, Doris; Ehscheidt, Peter; Feiten, Stefan

Health status and infections in patients with symptomatic primary and secondary immunoglobulin G (IgG) deficiencies receiving intravenous IgG replacement

Reference
management

Bookmarks

Remove from
bookmarks

Share this on Whatsapp

Close

Bookmarks



You can manage bookmarks using lists, please log in to your user account for this.
  • Media type: E-Article
  • Title: Health status and infections in patients with symptomatic primary and secondary immunoglobulin G (IgG) deficiencies receiving intravenous IgG replacement
  • Contributor: Weide, Rudolf; Schnell, Roland; Schardt, Christof; Koenigsmann, Michael; Otremba, Burkhard; Zahn, Mark-Oliver; Wierecky, Jan; Braun, Ute; Hensel, Manfred; Klausmann, Martine; Fleckenstein, Doris; Ehscheidt, Peter; Feiten, Stefan
  • imprint: Springer Science and Business Media LLC, 2020
  • Published in: BMC Immunology
  • Language: English
  • DOI: 10.1186/s12865-020-00368-7
  • ISSN: 1471-2172
  • Keywords: Immunology
  • Origination:
  • Footnote:
  • Description: <jats:title>Abstract</jats:title><jats:sec><jats:title>Background</jats:title><jats:p>The effects of intravenous immunoglobulin G replacement on perceived health and infection susceptibility of patients suffering from immunoglobulin G (IgG) deficiencies should be evaluated in a prospective analysis.</jats:p></jats:sec><jats:sec><jats:title>Methods</jats:title><jats:p>Patients with symptomatic primary or secondary IgG deficiencies were interviewed prior to the first IgG infusion (t<jats:sub>0</jats:sub>) and over the course of their treatment (t<jats:sub>1</jats:sub>- t<jats:sub>6</jats:sub>). The respondents rated their current health using a 100 point scale (EQ-5D-5L), ranging from 0 (‘worst imaginable health’) to 100 (‘best imaginable health’). The patients also provided information on the frequency of infections and of infections requiring antibiotics in the past 8 weeks. A healthy control group (CG) without oncologic diseases answered the questions once.</jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p>One hundred six patients with a median age of 65 years (21–85 years) were investigated. The median serum IgG concentration changed from 500 mg/dl (t<jats:sub>0</jats:sub>) to 772 mg/dl (t<jats:sub>6</jats:sub>). The mean number of infections and of infections requiring antibiotics decreased during IgG replacement significantly. Current health according to EQ-5D-5L improved from 57 (t<jats:sub>0</jats:sub>) to 68 (t<jats:sub>6</jats:sub>), compared to 73 in the CG.</jats:p></jats:sec><jats:sec><jats:title>Conclusion</jats:title><jats:p>During the course of IgG replacement patients reported fewer and less severe infections. Their health assessment improved but still was inferior to the healthy CG.</jats:p></jats:sec>
  • Access State: Open Access