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Media type:
E-Article
Title:
Wild-Type p53 Binds to the TATA-Binding Protein and Represses Transcription
Contributor:
Seto, Edward;
Usheva, Anny;
Zambetti, Gerard P.;
Momand, Jamil;
Horikoshi, Nobuo;
Weinmann, Roberto;
Levine, Arnold J.;
Shenk, Thomas
imprint:
National Academy of Sciences of the United States of America, 1992
Published in:Proceedings of the National Academy of Sciences of the United States of America
Language:
English
ISSN:
0027-8424
Origination:
Footnote:
Description:
<p>p53 activates transcription of genes with a p53 response element, and it can repress genes lacking the element. Here we demonstrate that wild-type but not mutant p53 inhibits transcription in a HeLa nuclear extract from minimal promoters. Wild-type but not mutant p53 binds to human TATA-binding protein (TBP). p53 does not bind to yeast TBP, and it cannot inhibit transcription in a HeLa extract where yeast TBP substitutes for human TBP. These results suggest a model in which p53 binds to TBP and interferes with transcriptional initiation.</p>