Töpperwien, Mareike
[VerfasserIn]
;
Salditt, Tim
[AkademischeR BetreuerIn];
Salditt, Tim
[Sonstige Person, Familie und Körperschaft];
Rehfeldt, Florian
[Sonstige Person, Familie und Körperschaft]
3d virtual histology of neuronal tissue by propagation-based x-ray phase-contrast tomography
Beschreibung:
Deciphering the three-dimensional (3d) cytoarchitecture of neuronal tissue is an important step towards understanding the connection between tissue function and structure and determining relevant changes in neurodegenerative diseases. The gold standard in pathology is histology, in which the tissue is examined under a light microscope after serial sectioning and subsequent staining. It is an invasive and labor-intensive technique which is prone to artifacts due to the slicing procedure. While it provides excellent results on the 2d slices, the 3d anatomy can only be determined after alignin...