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Liermann, Jakob [VerfasserIn]; Syed, Mustafa [VerfasserIn]; Held, Thomas [VerfasserIn]; Bernhardt, Denise [VerfasserIn]; Plinkert, Peter K. [VerfasserIn]; Jungk, Christine [VerfasserIn]; Unterberg, Andreas [VerfasserIn]; Rieken, Stefan [VerfasserIn]; Debus, Jürgen [VerfasserIn]; Herfarth, Klaus [VerfasserIn]; Adeberg, Sebastian [VerfasserIn]

Advanced radiation techniques in the treatment of esthesioneuroblastoma : a 7-year single-institution’s clinical experience

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  • Medientyp: E-Artikel
  • Titel: Advanced radiation techniques in the treatment of esthesioneuroblastoma : a 7-year single-institution’s clinical experience
  • Beteiligte: Liermann, Jakob [VerfasserIn]; Syed, Mustafa [VerfasserIn]; Held, Thomas [VerfasserIn]; Bernhardt, Denise [VerfasserIn]; Plinkert, Peter K. [VerfasserIn]; Jungk, Christine [VerfasserIn]; Unterberg, Andreas [VerfasserIn]; Rieken, Stefan [VerfasserIn]; Debus, Jürgen [VerfasserIn]; Herfarth, Klaus [VerfasserIn]; Adeberg, Sebastian [VerfasserIn]
  • Erschienen: 20 November 2018
  • Erschienen in: Cancers ; 10(2018), 11, Artikel-ID 457
  • Sprache: Englisch
  • DOI: 10.3390/cancers10110457
  • ISSN: 2072-6694
  • Identifikator:
  • Schlagwörter: carbon ion radiation ; esthesioneuroblastoma ; olfactory neuroblastoma ; particle therapy ; radiotherapy
  • Entstehung:
  • Anmerkungen:
  • Beschreibung: (1) Background: Esthesioneuroblastoma (ENB) is a rare tumor entity originating from the olfactory neuroepithelium. There is a scarcity of data about different treatment strategies. Intensity modulated radiotherapy (IMRT) and carbon ion radiotherapy (CIRT) are advanced radiation techniques that might improve local tumor control. (2) Methods: This retrospective analysis contained 17 patients with ENB (Kadish stage ≥ C: 88%; n = 15). Four patients had already undergone previous radiotherapy (RT). The treatment consisted of either IMRT (n = 5), CIRT (n = 4) or a combination of both techniques (n = 8). Median follow-up was 29 months. (3) Results: In patients that had not been irradiated before (n = 13), calculated overall survival (OS) and progression free survival (PFS) rates after 48 months were 100% and 81% respectively (Kaplan-Meier estimates). Two of four patients that underwent reirradiation died after RT, presumably due to tumor progression. Besides common toxicities, five patients (30%) showed mostly asymptomatic radiation-induced brain changes, most likely due to a disturbance of the blood-brain barrier. (4) Conclusions: Our results demonstrate that IMRT, CIRT, a combined approach of IMRT and CIRT as well as reirradiation with CIRT seem to be feasible and effective treatment methods in ENB.
  • Zugangsstatus: Freier Zugang