Penne, Alexander
[VerfasserIn]
;
Stracke, Sylvia
[AkademischeR BetreuerIn];
Weinmann-Menke, Julia
[AkademischeR BetreuerIn]Universität Greifswald
Einfluss eines Bluthochdruckes auf die Nierenfunktion (eGFR, ACR) in der Allgemeinbevölkerung über einen Beobachtungszeitraum von 15 Jahren (Study of Health in Pomerania)
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Titel:
Einfluss eines Bluthochdruckes auf die Nierenfunktion (eGFR, ACR) in der Allgemeinbevölkerung über einen Beobachtungszeitraum von 15 Jahren (Study of Health in Pomerania)
High blood pressure is considered one of the main risk factors for the progression of chronic kidney disease. Achieving a sufficient blood pressure adjustment to prevent the progression of chronic kidney disease is considered to have a high therapeutic relevance in everyday clinical practice, whereby longitudinal data on the effect of hypertension on renal function in kidney healthy people are only available in small numbers. The aim of the present study was to analyse this influence of hypertension in a kidney-healthy general population over a period of 15 years. Data from kidney-healthy participants in the SHIP study were evaluated to address the question. Based on the basic survey SHIP-0 (n=4042), we included the results of all 5-year follow-up studies up to SHIP-3. Using a mixed model, the course of renal function was presented on the one hand age- and gender-adjusted as well as for the exposures "phenotype hypertension" (defined as increased systolic or elevated diastolic blood pressure or if the interview-question of prescribing a drug for hypertension was answered with "yes" in the past 12 months) and "systolic blood pressure" (as a continuous variable) predicates the development of the eGFR as well as the ACR over time. Model prediction showed for the first four years of the study for hypertension (year 0: 102.8ml/min; CI 102.3-103.3ml/min) higher eGFR values than for non-hypertension (year 0: 101.2ml/min; CI 100.8-101.7ml/min), but over time there was a greater ...