Beschreibung:
Anti-CD20 antibody (ab) treatment exhibits an unprecedented therapeutic benefit in multiple sclerosis (MS). The very fact that B cell depletion is effective in a disease that was generally considered T cell-driven was astonishing. In addition to the extensive analysis of B cells, it also led to the discovery and the consideration of CD20+ T cells in MS pathology. CD20+ T cells are described as a small population of T cells that is increased in autoimmune diseases such as MS, but little else is known. Therefore, we wanted to understand which role CD20+ T cells play in MS and dissect whether ...