Immunological markers as predictors of developing steroid-induced diabetes mellitus in pemphigus vulgaris patients: An observational study

Medientyp: E-Book; Sonderdruck

Titel: Immunological markers as predictors of developing steroid-induced diabetes mellitus in pemphigus vulgaris patients: An observational study

Beteiligte: Dănescu, Ana Sorina [VerfasserIn]; Baldea, Ioana [VerfasserIn]; Leucuta, Daniel Corneliu [VerfasserIn]; Lupan, Iulia [VerfasserIn]; Samaşca, Gabriel [VerfasserIn]; Sitaru, Cassian [VerfasserIn]; Chiorean, Roxana [VerfasserIn]; Baican, Adrian [VerfasserIn]

Erschienen: Baltimore, Md.: Ovid Technologies (Wolters Kluwer Health), 2018

Umfang: 1 Online-Ressource (5 Seiten); Diagramme

Sprache: Englisch

DOI: 10.1097/md.0000000000010463

ISSN: 1536-5964

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Beschreibung: Abstract: The aim of this study was to evaluate the clinical importance of autoantibodies in pemphigus vulgaris patients who developed steroid-induced diabetes mellitus (SID) because of the glucocorticoid therapy of pemphigus. A total of 137 patients with pemphigus vulgaris were studied. Patients with SID and pemphigus were compared with those that had only pemphigus. The variables recorded were: age at diagnosis, sex, body mass index, presence of diabetes mellitus (DM), cumulative cortisone dose, treatment duration, value of anti-desmoglein 1 and 3, and anti-glutamic acid decarboxylase autoantibodies. A total of 31 patients (22.62%) that developed steroid-induced DM were identified. Anti-glutamic acid decarboxylase autoantibodies were positive in 20.75% of patients with pemphigus vulgaris and in 25.75% of patients with pemphigus vulgaris and SID. The overall anti-glutamic acid decarboxylase autoantibodies prevalence in pemphigus patients was high, and the risk of developing DM in patients with pemphigus remains a serious problem, being associated with increased risk of mortality

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