Genome-wide association analysis implicates dysregulation of immunity genes in chronic lymphocytic leukaemia

Medientyp: E-Book; Sonderdruck

Titel: Genome-wide association analysis implicates dysregulation of immunity genes in chronic lymphocytic leukaemia

Beteiligte: Law, Philip J. [VerfasserIn]; Berndt, Sonja I. [VerfasserIn]; Speedy, Helen E. [VerfasserIn]; Camp, Nicola Jane [VerfasserIn]; Sava, Georgina P. [VerfasserIn]; Skibola, Christine F. [VerfasserIn]; Nieters, Alexandra [VerfasserIn]; Houlston, Richard [VerfasserIn]; Slager, Susan L. [VerfasserIn]

Erschienen: London: Nature Publishing Group UK, 2017

Umfang: 1 Online-Ressource (12 Seiten); Diagramme; Supplementary information (1 ZIP-Datei: 2 PDF-Dateien, 3 .xlsx-Dateien)

Sprache: Englisch

DOI: 10.1038/ncomms14175

ISSN: 2041-1723

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Beschreibung: Abstract: Several chronic lymphocytic leukaemia (CLL) susceptibility loci have been reported; however, much of the heritable risk remains unidentified. Here we perform a meta-analysis of six genome-wide association studies, imputed using a merged reference panel of 1,000 Genomes and UK10K data, totalling 6,200 cases and 17,598 controls after replication. We identify nine risk loci at 1p36.11 (rs34676223, P=5.04 × 10−13), 1q42.13 (rs41271473, P=1.06 × 10−10), 4q24 (rs71597109, P=1.37 × 10−10), 4q35.1 (rs57214277, P=3.69 × 10−8), 6p21.31 (rs3800461, P=1.97 × 10−8), 11q23.2 (rs61904987, P=2.64 × 10−11), 18q21.1 (rs1036935, P=3.27 × 10−8), 19p13.3 (rs7254272, P=4.67 × 10−8) and 22q13.33 (rs140522, P=2.70 × 10−9). These new and established risk loci map to areas of active chromatin and show an over-representation of transcription factor binding for the key determinants of B-cell development and immune response

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