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John, Caroline [VerfasserIn]; Dal Bello, Riccardo [VerfasserIn]; Andratschke, Nicolaus [VerfasserIn]; Guckenberger, Matthias [VerfasserIn]; Boda-Heggemann, Judit [VerfasserIn]; Gkika, Eleni [VerfasserIn]; Mantel, Frederick [VerfasserIn]; Specht, Hanno Martin [VerfasserIn]; Stromberger, Carmen [VerfasserIn]; Zehentmayr, Franz [VerfasserIn]; Blanck, Oliver [VerfasserIn]; Balermpas, Panagiotis [VerfasserIn]

In-field stereotactic body radiotherapy (SBRT) reirradiation for pulmonary malignancies as a multicentre analysis of the German Society of Radiation Oncology (DEGRO)

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  • Medientyp: E-Book; Sonderdruck
  • Titel: In-field stereotactic body radiotherapy (SBRT) reirradiation for pulmonary malignancies as a multicentre analysis of the German Society of Radiation Oncology (DEGRO)
  • Beteiligte: John, Caroline [VerfasserIn]; Dal Bello, Riccardo [VerfasserIn]; Andratschke, Nicolaus [VerfasserIn]; Guckenberger, Matthias [VerfasserIn]; Boda-Heggemann, Judit [VerfasserIn]; Gkika, Eleni [VerfasserIn]; Mantel, Frederick [VerfasserIn]; Specht, Hanno Martin [VerfasserIn]; Stromberger, Carmen [VerfasserIn]; Zehentmayr, Franz [VerfasserIn]; Blanck, Oliver [VerfasserIn]; Balermpas, Panagiotis [VerfasserIn]
  • Erschienen: London: Springer Nature, 2021
  • Erschienen in: Scientific reports ; 11, 1 (2021), 4590
  • Umfang: 1 Online-Ressource (11 Seiten); Diagramme; Supplementary information (1 ZIP-Datei: 3 .docx-Dateien)
  • Sprache: Englisch
  • DOI: 10.1038/s41598-021-83210-3
  • ISSN: 2045-2322
  • Identifikator:
  • Entstehung:
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  • Beschreibung: Abstract: Data of thoracic in-field reirradiation with two courses of stereotactic body radiotherapy (SBRT) is scarce. Aim of this study is to investigate feasibility and safety of this approach. Patients with a second course of thoracic SBRT and planning target volume (PTV) overlap were analyzed in this retrospective, multicenter study. All plans and clinical data were centrally collected. 27 patients from 8 centers have been amenable for evaluation: 12 with non-small-cell lung cancer, 16 with metastases, treated from 2009 (oldest first course) to 2020 (latest second course). A median dose of 38.5 Gy to the 65%-isodose over a median of 5 fractions was prescribed in the first course and 40 Gy in 5 fractions for the second SBRT-course. Median PTV of the second SBRT was 29.5 cm3, median PTV overlap 22 cm3. With a median interval of 20.2 months between the two SBRT-courses, 1-year OS, and -LCR were 78.3% and 70.3% respectively. 3 patients developed grade 1 and one grade 2 pneumonitis. No grade > 2 toxicity was observed. Peripheral location and dose were the only factors correlating with tumor control. A second SBRT-course with PTV overlap appears safe and achieves reasonable local control
  • Zugangsstatus: Freier Zugang