Beschreibung:
Despite ever-evolving treatment and screening procedures, Colorectal cancer (CRC) remains a major cause of cancer-related deaths worldwide. Preoperative chemoradiotherapy (CRT), followed by standardized surgical resection of the tumor, represents the standard treatment for locally advanced rectal cancers. However, tumor cells can possess or acquire resistance to CRT, so that affected patients do not benefit from treatment but are afflicted with potential negative side-effects of anti-cancer treatment without any clinical benefit. Therefore, the resistance of tumor cells to CRT represents a ...