Congenital Toxoplasmosis in Austria: Prenatal Screening for Prevention is Cost-Saving

Medientyp: E-Book

Titel: Congenital Toxoplasmosis in Austria : Prenatal Screening for Prevention is Cost-Saving

Beteiligte: Prusa, Andrea-Romana [VerfasserIn]; Kasper, David C. [Sonstige Person, Familie und Körperschaft]; Sawers, Larry [Sonstige Person, Familie und Körperschaft]; Walter, Evelyn [Sonstige Person, Familie und Körperschaft]; Hayde, Michael [Sonstige Person, Familie und Körperschaft]; Stillwaggon, Eileen [Sonstige Person, Familie und Körperschaft]

Erschienen: [S.l.]: SSRN, [2018]

Umfang: 1 Online-Ressource (34 p)

Sprache: Englisch

Entstehung:

Anmerkungen: In: (2017). PLoS Negl Trop Dis 11(7): e0005648. DOI/10.1371/journal.pntd.0005648
Nach Informationen von SSRN wurde die ursprüngliche Fassung des Dokuments December 14, 2016 erstellt

Beschreibung: Background: Primary infection of Toxoplasma gondii during pregnancy can be transmitted to the unborn child and may have serious consequences, including retinochoroiditis, hydrocephaly, cerebral calcifications, encephalitis, splenomegaly, hearing loss, blindness, and death. Austria, a country with moderate seroprevalence, instituted mandatory prenatal screening for toxoplasma infection to minimize the effects of congenital transmission. This work compares the societal costs of congenital toxoplasmosis under the Austrian national prenatal screening program with the societal costs that would have occurred in a No-Screening scenario.Methodology/Principal findings: We retrospectively investigated data from the Austrian Toxoplasmosis Register for birth cohorts from 1992 to 2008, including pediatric long-term follow-up until May 2013. We constructed a decision-analytic model to compare lifetime societal costs of prenatal screening with lifetime societal costs estimated in a No-Screening scenario. We included costs of treatment, lifetime care, accommodation of injuries, loss of life, and lost earnings that would have occurred in a No-Screening scenario and compared them with the actual costs of screening, treatment, lifetime care, accommodation, loss of life, and lost earnings. We replicated that analysis excluding loss of life and lost earnings to estimate the budgetary impact alone.Our model calculated total lifetime costs of €103 per birth under prenatal screening as carried out in Austria, saving €323 per birth compared with No-Screening. Without screening and treatment, lifetime societal costs for all affected children would have been €35 million per year; the implementation costs of the Austrian program are less than €2 million per year. Calculating only the budgetary impact, the national program was still cost-saving by more than €15 million per year and saved €258 million in 17 years.Conclusions/Significance: Cost savings under a national program of prenatal screening for toxoplasma infection and treatment are outstanding. Our results are of relevance for health care providers by supplying economic data based on a unique national dataset including long-term follow-up of affected infants

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