Beschreibung:
Abstract Autoimmune diseases are caused by an attack of the immune system against own tissues, but the exact effector mechanisms may vary between individual diseases and are not yet fully understood. The autoimmune disease multiple sclerosis (MS) is characterized by autoimmune damage of the myelin sheets in the central nervous system (CNS). There is a general consensus that the autoimmune process is mainly driven by encephalitogenic T cells, but the role of B cells in the pathogenesis of MS has also recently been appreciated. Previous work in our department has focused on the role of myelin...