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Pertz, Milena
[VerfasserIn];
Schlömer, Sabine
[VerfasserIn];
Seidel, Clemens
[VerfasserIn];
Hentschel, Bettina
[VerfasserIn];
Löffler, Markus
[VerfasserIn];
Schackert, Gabriele
[VerfasserIn];
Krex, Dietmar
[VerfasserIn];
Juratli, Tareq
[VerfasserIn];
Tonn, Joerg Christian
[VerfasserIn];
Schnell, Oliver
[VerfasserIn];
Vatter, Hartmut
[VerfasserIn];
Simon, Matthias
[VerfasserIn];
Westphal, Manfred
[VerfasserIn];
Martens, Tobias
[VerfasserIn];
Sabel, Michael
[VerfasserIn];
Bendszus, Martin
[VerfasserIn];
Dörner, Nils
[VerfasserIn];
Wick, Antje
[VerfasserIn];
Fliessbach, Klaus
[VerfasserIn];
Hoppe, Christian
[VerfasserIn];
Klingner, Marcel
[VerfasserIn];
Felsberg, Jörg
[VerfasserIn];
Reifenberger, Guido
[VerfasserIn];
Gramatzki, Dorothee
[VerfasserIn];
[...]
Long-term neurocognitive function and quality of life after multimodal therapy in adult glioma patients
: a prospective long-term follow-up
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- Medientyp: E-Artikel
- Titel: Long-term neurocognitive function and quality of life after multimodal therapy in adult glioma patients : a prospective long-term follow-up
- Beteiligte: Pertz, Milena [VerfasserIn]; Schlömer, Sabine [VerfasserIn]; Seidel, Clemens [VerfasserIn]; Hentschel, Bettina [VerfasserIn]; Löffler, Markus [VerfasserIn]; Schackert, Gabriele [VerfasserIn]; Krex, Dietmar [VerfasserIn]; Juratli, Tareq [VerfasserIn]; Tonn, Joerg Christian [VerfasserIn]; Schnell, Oliver [VerfasserIn]; Vatter, Hartmut [VerfasserIn]; Simon, Matthias [VerfasserIn]; Westphal, Manfred [VerfasserIn]; Martens, Tobias [VerfasserIn]; Sabel, Michael [VerfasserIn]; Bendszus, Martin [VerfasserIn]; Dörner, Nils [VerfasserIn]; Wick, Antje [VerfasserIn]; Fliessbach, Klaus [VerfasserIn]; Hoppe, Christian [VerfasserIn]; Klingner, Marcel [VerfasserIn]; Felsberg, Jörg [VerfasserIn]; Reifenberger, Guido [VerfasserIn]; Gramatzki, Dorothee [VerfasserIn]; Weller, Michael [VerfasserIn]; Schlegel, Uwe [VerfasserIn]
- Erschienen: 30 August 2023
- Erschienen in: Journal of neuro-oncology ; 164(2023), 2, Seite 353-366
- Sprache: Englisch
- DOI: 10.1007/s11060-023-04419-y
- ISSN: 1573-7373
- Identifikator:
- Schlagwörter: Glioma ; Multimodal tumor-directed treatment ; Neurocognition ; Quality of life ; Radiotherapy
- Entstehung:
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Anmerkungen:
Online veröffentlicht: 30. August 2023
- Beschreibung: Purpose: Multimodal therapies have significantly improved prognosis in glioma. However, in particular radiotherapy may induce long-term neurotoxicity compromising patients’ neurocognition and quality of life. The present prospective multicenter study aimed to evaluate associations of multimodal treatment with neurocognition with a particular focus on hippocampal irradiation. Methods: Seventy-one glioma patients (WHO grade 1–4) were serially evaluated with neurocognitive testing and quality of life questionnaires. Prior to (baseline) and following further treatment (median 7.1 years [range 4.6–11.0] after baseline) a standardized computerized neurocognitive test battery (NeuroCog FX) was applied to gauge psychomotor speed and inhibition, verbal short-term memory, working memory, verbal and non-verbal memory as well as verbal fluency. Mean ipsilateral hippocampal radiation dose was determined in a subgroup of 27 patients who received radiotherapy according to radiotherapy plans to evaluate its association with neurocognition. Results: Between baseline and follow-up mean performance in none of the cognitive domains significantly declined in any treatment modality (radiotherapy, chemotherapy, combined radio-chemotherapy, watchful-waiting), except for selective attention in patients receiving chemotherapy alone. Apart from one subtest (inhibition), mean ipsilateral hippocampal radiation dose > 50 Gy (Dmean) as compared to < 10 Gy showed no associations with long-term cognitive functioning. However, patients with Dmean < 10 Gy showed stable or improved performance in all cognitive domains, while patients with > 50 Gy numerically deteriorated in 4/8 domains. Conclusions: Multimodal glioma therapy seems to affect neurocognition less than generally assumed. Even patients with unilateral hippocampal irradiation with > 50 Gy showed no profound cognitive decline in this series.
- Zugangsstatus: Freier Zugang