Beschreibung:
Neuronal microcircuit is built by neurons connected with dynamic synapses. Short-term synaptic plasticity is one form of the synaptic dynamics, which plays various roles in the circuit information processing and computation.Feed-forward inhibitory circuit is composed of an excitatory input synapse, an interneuron and an inhibitory output synapse. Two cerebellar FFI circuits (basket cell mediating somatic FFI and stellate cell mediating dendritic FFI) have been analyzed in parallel in this work to compare their input/output synaptic dynamics, the intrinsic firing property of interneurons and the circuit output dynamics. It is shown that these two FFI circuits differe only on their input synaptic dynamics, and their circuit output dynamics are tightly regulated by the input synaptic dynamics.