Animal Cell Biotechnology: In Biologics Production

Medientyp: E-Book

Titel: Animal Cell Biotechnology : In Biologics Production

Enthält: FrontmatterPrefaceContentsList of Contributing Authors1.1 Industrial Use and Perspectives of Animal Cell Culture / Wagner, Roland ; Hauser, Hansjörg
2.1 Generation of Cell Lines and Biotechnological Applications / Lipps, Christoph ; May, Tobias ; Wirth, Dagmar
2.2 CHO History, CHO Evolution and CHO Genomics – an Unsolvable Enigma? / Wurm, Florian M.
2.3 Cell Lines for Vaccine Production / Jordan, Ingo ; Sandig, Volker
2.4 Cell Line Monitoring: Molecular Cytogenetic Characterization / MacLeod, Roderick A. F. ; Drexler, Hans G.
2.5 Quality Control Essentials in Human Cell Culture: Cell Line Cross-contamination and Microbiological Infections / Dirks, Wilhelm G. ; Uphoff, Cord C.
3.1 Cell Line Evolution and Engineering / Kaufmann, Hitto
3.2 Chromosome Rearrangements and Gene Amplification / Omasa, Takeshi ; Lee, Kyoungho
3.3 Synthetic Biology Principles for Engineering Mammalian Designer Cells / Ausländer, David ; Fussenegger, Martin
3.4 Rational Approaches for Transgene Expression: Targeted Integration and Episomal Maintenance / Kruse, Natascha ; Spencer, Shawal ; Wirth, Dagmar
3.5 Manipulation of Cell Growth, Metabolism and Product Quality Attributes / Henning von Horsten, Hans ; Winkler, Karsten ; Sandig, Volker
4.1 Control of Biotheraputics Glycosylation / Bennun, Sandra V. ; Heffner, Kelley M. ; Blake, Emily ; Chung, Andrew ; Betenbaugh, Michael J.
4.2 Manufacturing of Complex Biotherapeutic Protein Products: Medical Need and Rational for Monoclonal Antibody Mixtures, Multispecific Formats, and Fc-fusion Proteins / Florin, Lore ; Rasmussen, Sören K. ; Frandsen, Torben P. ; Tolstrup, Anne B.
5.1 Physiology and Metabolism of Animal Cells for Production / Tayi, Venkata ; Butler, Michael
5.2 Functional -Omics for Cell Lines and Processes: The -Omics Technologies on the Example of CHO Cells / Brinkrolf, Karina ; Hoffrogge, Raimund ; Hackl, Matthias ; Tauch, Andreas ; Baumann, Martina ; Noll, Thomas ; Goesmann, Alexander ; Pühler, Alfred ; Borth, Nicole
5.3 Nutrient Media for Cell Culture Technology / Altamirano, Claudia ; Berrios, Julio ; Vergara, Mauricio
6.1 Bioreactors for Animal Cell Culture / Eisenkraetzer, Detlef
6.2 High Cell Density Cultivation Process / Ceaglio, Natalia ; Bollati-Fogolín, Mariela ; Oggero, Marcos ; Etcheverrigaray, Marina ; Kratje, Ricardo
6.3 Industrial Cell Culture Process Scale-up Strategies and Considerations / Hu, Weiwei ; Wiltberger, Kelly
6.4 Extraction and Purification of Biologics from Cell Culture: Monoclonal Antibody Downstream Processing / Fontes, Nuno ; Zhang, Ruoheng ; Vogel, Jens H.
7.1 Concepts and Technologies for Advanced Process Monitoring and Control / Smelko, John Paul ; Ryll, Thomas ; Müller, Dethardt
7.2 Analytical Techniques and Quality Control of Protein Therapeutics / Hong Que, Amy ; Wang, Yang ; Ziyi Kan, Steven
7.3 Process Characterization for Upstream and Downstream Process Development / Janakiraman, Vijay ; Westoby, Matthew ; Conley, Lynn
8.1 Spatiotemporally Controlled Delivery of Biopharmaceuticals / Rebmann, Balder ; van Hoogevest, Peter ; Zurbriggen, Matias ; Weber, Wilfried
Index.

Beteiligte: Hauser, Hansjörg [Sonstige Person, Familie und Körperschaft]; Wagner, Roland [Sonstige Person, Familie und Körperschaft]

Erschienen: Berlin: De Gruyter, 2014

Umfang: Online-Ressource (XV, 702 S.)

Sprache: Englisch

DOI: 10.1515/9783110278965

ISBN: 9783110278965; 9783110278866

Identifikator:

RVK-Notation: WX 6600 : Allgemeines
WF 9720 : Bioverfahrenstechnik

Schlagwörter: Biologika > Tierzelle > Zellkultur > Biotechnologie

Entstehung:

Anmerkungen:

Beschreibung: Main description: This book introduces the fundamental principles and practical application of techniques used in the scalable production of proteins and virus-based gene-therapeutic products with animal cell cultures. The book reviews a broad spectrum of subjects relevant to biologics production, including the creation of cell lines, a survey of functional genomics for cell lines and processes, and advances in upstream and downstream process development. It is an essential reference for all those working in the biotechnology field both from an academic and industrial standpoint.

This book introduces the fundamental principles and practical application of techniques used in the scalable production of proteins and virus-based gene-therapeutic products with animal cell cultures. The book reviews a broad spectrum of subjects relevant to biologics production, including the creation of cell lines, a survey of functional genomics for cell lines and processes, and advances in upstream and downstream process development. It is an essential reference for all those working in the biotechnology field both from an academic and industrial standpoint.

This book introduces the fundamental principles and practical application of techniques used in the scalable production of proteins and virus-based gene-therapeutic products with animal cell cultures. The book reviews a broad spectrum of subjects relevant to biologics production, including the creation of cell lines, a survey of functional genomics for cell lines and processes, and advances in upstream and downstream process development. It is an essential reference for all those working in the biotechnology field both from an academic and industrial standpoint. Hansjörg Hauser, Helmholtz Centre for Infection Research, Braunschweig; Roland Wagner, Rentschler Biotechnologie GmbH, Laupheim

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