Schulze, Marcel
[VerfasserIn];
Sörös, Peter
[VerfasserIn];
Vogel, Wolfgang
[VerfasserIn];
Münte, Thomas Frank
[VerfasserIn];
Müller, Helge H. O.
[VerfasserIn];
Philipsen, Alexandra
[VerfasserIn]
Impact of bariatric surgery on neural food processing and cognition: an fMRI study
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Medientyp:
E-Artikel
Titel:
Impact of bariatric surgery on neural food processing and cognition: an fMRI study
Beteiligte:
Schulze, Marcel
[VerfasserIn];
Sörös, Peter
[VerfasserIn];
Vogel, Wolfgang
[VerfasserIn];
Münte, Thomas Frank
[VerfasserIn];
Müller, Helge H. O.
[VerfasserIn];
Philipsen, Alexandra
[VerfasserIn]
Erschienen:
Carl von Ossietzky Universität Oldenburg: /oops/ - Oldenburger Online-Publikations-Server, 2018-09-28
Anmerkungen:
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Beschreibung:
Introduction The Roux-en-Y gastric bypass (RYGB) is one of the most widely used techniques for bariatric surgery. After RYGB, weight loss up to 50%–70% of excess body weight, improvement of insulin-resistance, changes in food preferences and improvements in cognitive performance have been reported. This protocol describes a longitudinal study of the neural correlates associated with food-processing and cognitive performance in patients with morbid obesity before and after RYGB relative to lean controls. Methods and analysis This study is a pre–post case– control experiment. Using functional MRI, the neural responses to food stimuli and a working memory task will be compared between 25 patients with obesity, pre and post RYGB, and a matched, lean control group. Resting state fMRI will be measured to investigate functional brain connectivity. Baseline measurements for both groups will take place 4 weeks prior to RYGB and 12 months after RYGB. The effects of RYGB on peptide tyrosine tyrosine and glucagon-like polypeptide-1 will also be determined. Ethics and dissemination The project has received ethical approval by the local medical ethics committee of the Carl-von-Ossietzky University of Oldenburg, Germany (registration: 2017-073). Results will be published in a peer-reviewed journal as original research and on international conferences.