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Ciolac, Dumitru [VerfasserIn]; Gonzalez‐Escamilla, Gabriel [VerfasserIn]; Winter, Yaroslav [VerfasserIn]; Melzer, Nico [VerfasserIn]; Luessi, Felix [VerfasserIn]; Radetz, Angela [VerfasserIn]; Fleischer, Vinzenz [VerfasserIn]; Groppa, Stanislav A. [VerfasserIn]; Kirsch, Michael [VerfasserIn]; Bittner, Stefan [VerfasserIn]; Zipp, Frauke [VerfasserIn]; Muthuraman, Muthuraman [VerfasserIn]; Meuth, Sven G. [VerfasserIn]; Grothe, Matthias [VerfasserIn]; Groppa, Sergiu [VerfasserIn]

Altered grey matter integrity and network vulnerability relate to epilepsy occurrence in patients with multiple sclerosis

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  • Medientyp: E-Artikel
  • Titel: Altered grey matter integrity and network vulnerability relate to epilepsy occurrence in patients with multiple sclerosis
  • Beteiligte: Ciolac, Dumitru [VerfasserIn]; Gonzalez‐Escamilla, Gabriel [VerfasserIn]; Winter, Yaroslav [VerfasserIn]; Melzer, Nico [VerfasserIn]; Luessi, Felix [VerfasserIn]; Radetz, Angela [VerfasserIn]; Fleischer, Vinzenz [VerfasserIn]; Groppa, Stanislav A. [VerfasserIn]; Kirsch, Michael [VerfasserIn]; Bittner, Stefan [VerfasserIn]; Zipp, Frauke [VerfasserIn]; Muthuraman, Muthuraman [VerfasserIn]; Meuth, Sven G. [VerfasserIn]; Grothe, Matthias [VerfasserIn]; Groppa, Sergiu [VerfasserIn]
  • Erschienen: Augsburg University Publication Server (OPUS), 2022
  • Sprache: Englisch
  • DOI: https://doi.org/10.1111/ene.15405
  • Entstehung:
  • Anmerkungen: Diese Datenquelle enthält auch Bestandsnachweise, die nicht zu einem Volltext führen.
  • Beschreibung: Background and purpose: The aim of this study was to investigate the relevance of compartmentalized grey matter (GM) pathology and network reorganization in multiple sclerosis (MS) patients with concomitant epilepsy. Methods: From 3-T magnetic resonance imaging scans of 30 MS patients with epilepsy (MSE group; age 41 ± 15 years, 21 females, disease duration 8 ± 6 years, median Expanded Disability Status Scale [EDSS] score 3), 60 MS patients without epilepsy (MS group; age 41 ± 12 years, 35 females, disease duration 6 ± 4 years, EDSS score 2), and 60 healthy subjects (HS group; age 40 ± 13 years, 27 females) the regional volumes of GM lesions and of cortical, subcortical and hippocampal structures were quantified. Network topology and vulnerability were modelled within the graph theoretical framework. Receiver-operating characteristic (ROC) curve analysis was applied to assess the accuracy of GM pathology measures to discriminate between MSE and MS patients. Results: Higher lesion volumes within the hippocampus, mesiotemporal cortex and amygdala were detected in the MSE compared to the MS group (all p < 0.05). The MSE group had lower cortical volumes mainly in temporal and parietal areas compared to the MS and HS groups (all p < 0.05). Lower hippocampal tail and presubiculum volumes were identified in both the MSE and MS groups compared to the HS group (all p < 0.05). Network topology in the MSE group was characterized by higher transitivity and assortativity, and higher vulnerability compared to the MS and HS groups (all p < 0.05). Hippocampal lesion volume yielded the highest accuracy (area under the ROC curve 0.80 [0.67–0.91]) in discriminating between MSE and MS patients. Conclusions: High lesion load, altered integrity of mesiotemporal GM structures, and network reorganization are associated with a greater propensity for epilepsy occurrence in people with MS.
  • Zugangsstatus: Freier Zugang