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Heunis, Stephan [VerfasserIn]; Breeuwer, Marcel [VerfasserIn]; Caballero-Gaudes, César [VerfasserIn]; Hellrung, Lydia [VerfasserIn]; Huijbers, Willem [VerfasserIn]; Jansen, Jacobus FA [VerfasserIn]; Lamerichs, Rolf [VerfasserIn]; Zinger, Svitlana [VerfasserIn]; Aldenkamp, Albert P [VerfasserIn]

The effects of multi-echo fMRI combination and rapid T*-mapping on offline and real-time BOLD sensitivity

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  • Medientyp: E-Artikel
  • Titel: The effects of multi-echo fMRI combination and rapid T*-mapping on offline and real-time BOLD sensitivity
  • Beteiligte: Heunis, Stephan [VerfasserIn]; Breeuwer, Marcel [VerfasserIn]; Caballero-Gaudes, César [VerfasserIn]; Hellrung, Lydia [VerfasserIn]; Huijbers, Willem [VerfasserIn]; Jansen, Jacobus FA [VerfasserIn]; Lamerichs, Rolf [VerfasserIn]; Zinger, Svitlana [VerfasserIn]; Aldenkamp, Albert P [VerfasserIn]
  • Erschienen: Academic Press, 2021
  • Erschienen in: NeuroImage 238, 118244 - (2021). doi:10.1016/j.neuroimage.2021.118244
  • Sprache: Englisch
  • DOI: https://doi.org/10.1016/j.neuroimage.2021.118244
  • ISSN: 1095-9572; 1053-8119
  • Entstehung:
  • Anmerkungen: Diese Datenquelle enthält auch Bestandsnachweise, die nicht zu einem Volltext führen.
  • Beschreibung: A variety of strategies are used to combine multi-echo functional magnetic resonance imaging (fMRI) data, yet recent literature lacks a systematic comparison of the available options. Here we compare six different approaches derived from multi-echo data and evaluate their influences on BOLD sensitivity for offline and in particular real-time use cases: a single-echo time series (based on Echo 2), the real-time T2*-mapped time series (T2*FIT) and four combined time series (T2*-weighted, tSNR-weighted, TE-weighted, and a new combination scheme termed T2*FIT-weighted). We compare the influences of these six multi-echo derived time series on BOLD sensitivity using a healthy participant dataset (N = 28) with four task-based fMRI runs and two resting state runs. We show that the T2*FIT-weighted combination yields the largest increase in temporal signal-to-noise ratio across task and resting state runs. We demonstrate additionally for all tasks that the T2*FIT time series consistently yields the largest offline effect size measures and real-time region-of-interest based functional contrasts and temporal contrast-to-noise ratios. These improvements show the promising utility of multi-echo fMRI for studies employing real-time paradigms, while further work is advised to mitigate the decreased tSNR of the T2*FIT time series. We recommend the use and continued exploration of T2*FIT for offline task-based and real-time region-based fMRI analysis. Supporting information includes: a data repository (https://dataverse.nl/dataverse/rt-me-fmri), an interactive web-based application to explore the data (https://rt-me-fmri.herokuapp.com/), and further materials and code for reproducibility (https://github.com/jsheunis/rt-me-fMRI).
  • Zugangsstatus: Freier Zugang