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Kaulen, Nicolas [VerfasserIn]; Rajkumar, Ravichandran [VerfasserIn]; Scheins, Jürgen [VerfasserIn]; Neumaier, Bernd [VerfasserIn]; Ermert, Johannes [VerfasserIn]; Herzog, Hans [VerfasserIn]; Langen, Karl-Joseph [VerfasserIn]; Lerche, Christoph [VerfasserIn]; Shah, N. J. [VerfasserIn]; Veselinović, Tanja [VerfasserIn]; Neuner, Irene [VerfasserIn]; Régio Brambilla, Cláudia [VerfasserIn]; Mauler, Jörg [VerfasserIn]; Ramkiran, Shukti [VerfasserIn]; Orth, Linda [VerfasserIn]; Sbaihat, Hasan [VerfasserIn]; Lang, Markus [VerfasserIn]; Wyss, Christine [VerfasserIn]; Rota Kops, Elena [VerfasserIn]

mGluR 5 and GABA A receptor‐specific parametric PET atlas construction— PET / MR data processing pipeline, validation, and application

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  • Medientyp: E-Artikel
  • Titel: mGluR 5 and GABA A receptor‐specific parametric PET atlas construction— PET / MR data processing pipeline, validation, and application
  • Beteiligte: Kaulen, Nicolas [VerfasserIn]; Rajkumar, Ravichandran [VerfasserIn]; Scheins, Jürgen [VerfasserIn]; Neumaier, Bernd [VerfasserIn]; Ermert, Johannes [VerfasserIn]; Herzog, Hans [VerfasserIn]; Langen, Karl-Joseph [VerfasserIn]; Lerche, Christoph [VerfasserIn]; Shah, N. J. [VerfasserIn]; Veselinović, Tanja [VerfasserIn]; Neuner, Irene [VerfasserIn]; Régio Brambilla, Cláudia [VerfasserIn]; Mauler, Jörg [VerfasserIn]; Ramkiran, Shukti [VerfasserIn]; Orth, Linda [VerfasserIn]; Sbaihat, Hasan [VerfasserIn]; Lang, Markus [VerfasserIn]; Wyss, Christine [VerfasserIn]; Rota Kops, Elena [VerfasserIn]
  • Erschienen: Wiley-Liss, 2022
  • Erschienen in: Human brain mapping 43(7), 2148-2163 (2022). doi:10.1002/hbm.25778
  • Sprache: Englisch
  • DOI: https://doi.org/10.1002/hbm.25778
  • ISSN: 1065-9471; 1097-0193
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  • Beschreibung: The glutamate and γ-aminobutyric acid neuroreceptor subtypes mGluR5 and GABAA are hypothesized to be involved in the development of a variety of psychiatric diseases. However, detailed information relating to their in vivo distribution is generally unavailable. Maps of such distributions could potentially aid clinical studies by providing a reference for the normal distribution of neuroreceptors and may also be useful as covariates in advanced functional magnetic resonance imaging (MR) studies. In this study, we propose a comprehensive processing pipeline for the construction of standard space, in vivo distributions of non-displaceable binding potential (BPND), and total distribution volume (VT) based on simultaneously acquired bolus-infusion positron emission tomography (PET) and MR data. The pipeline was applied to [11C]ABP688-PET/MR (13 healthy male non-smokers, 26.6 ± 7.0 years) and [11C]Flumazenil-PET/MR (10 healthy males, 25.8 ± 3.0 years) data. Activity concentration templates, as well as VT and BPND atlases of mGluR5 and GABAA, were generated from these data. The maps were validated by assessing the percent error δ from warped space to native space in a selection of brain regions. We verified that the average δABP = 3.0 ± 1.0% and δFMZ = 3.8 ± 1.4% were lower than the expected variabilities σ of the tracers (σABP = 4.0%–16.0%, σFMZ = 3.9%–9.5%). An evaluation of PET-to-PET registrations based on the new maps showed higher registration accuracy compared to registrations based on the commonly used [15O]H2O-template distributed with SPM12. Thus, we conclude that the resulting maps can be used for further research and the proposed pipeline is a viable tool for the construction of standardized PET data distributions.
  • Zugangsstatus: Freier Zugang