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Background Perfusion MRI is a well-established imaging modality with a multitude of applications in oncological and cardiovascular imaging. Clinically used processing methods, while stable and robust, have remained largely unchanged in recent years. Despite promising results from novel methods, their relatively minimal improvement compared to established methods did not generally warrant significant changes to clinical perfusion processing.</jats:p><jats:p>
Results and Conclusion Machine learning in general and deep learning in particular, which are currently revolutionizing computer-aided diagnosis, may carry the potential to change this situation and truly capture the potential of perfusion imaging. Recent advances in the training of recurrent neural networks make it possible to predict and classify time series data with high accuracy. Combining physics-based tissue models and deep learning, using either physics-informed neural networks or universal differential equations, simplifies the training process and increases the interpretability of the resulting models. Due to their versatility, these methods will potentially be useful in bridging the gap between microvascular architecture and perfusion parameters, akin to MR fingerprinting in structural MR imaging. Still, further research is urgently needed before these methods may be used in clinical practice.</jats:p><jats:p>
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