The immunopeptidomic landscape of ovarian carcinomas

Medientyp: E-Artikel
Titel: The immunopeptidomic landscape of ovarian carcinomas
Beteiligte: Schuster, Heiko; Peper, Janet K.; Bösmüller, Hans-Christian; Röhle, Kevin; Backert, Linus; Bilich, Tatjana; Ney, Britta; Löffler, Markus W.; Kowalewski, Daniel J.; Trautwein, Nico; Rabsteyn, Armin; Engler, Tobias; Braun, Sabine; Haen, Sebastian P.; Walz, Juliane S.; Schmid-Horch, Barbara; Brucker, Sara Y.; Wallwiener, Diethelm; Kohlbacher, Oliver; Fend, Falko; Rammensee, Hans-Georg; Stevanović, Stefan; Staebler, Annette; Wagner, Philipp
Erschienen: Proceedings of the National Academy of Sciences, 2017
Erschienen in: Proceedings of the National Academy of Sciences
Sprache: Englisch
DOI: 10.1073/pnas.1707658114
ISSN: 0027-8424; 1091-6490
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Beschreibung: <jats:title>Significance</jats:title> <jats:p>Despite the revolution in cancer therapy initiated by checkpoint inhibitors, durable clinical responses remain sporadic in many types of cancer, including ovarian cancer. Understanding which antigens are essentially presented by tumor cells and further able to be recognized by T cells provides a major step toward novel effective targeted immunotherapies. In this study, we comprehensively analyzed the immunopeptidomic landscape of ovarian carcinoma and compared it to variety of benign sources to identify antigens exclusively presented on tumor cells. With personalized therapies moving into the focus of clinical cancer therapy, we further present insights on how gene-expression analysis and immunohistochemistry can support antigen selection for individualized immunotherapy.</jats:p>
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