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Smit, Wouter Laurentius; Spaan, Claudia Nanette; Johannes de Boer, Ruben; Ramesh, Prashanthi; Martins Garcia, Tânia; Meijer, Bartolomeus Joannes; Vermeulen, Jacqueline Ludovicus Maria; Lezzerini, Marco; MacInnes, Alyson Winfried; Koster, Jan; Medema, Jan Paul; van den Brink, Gijs Robert; Muncan, Vanesa; Heijmans, Jarom

Driver mutations of the adenoma-carcinoma sequence govern the intestinal epithelial global translational capacity

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  • Medientyp: E-Artikel
  • Titel: Driver mutations of the adenoma-carcinoma sequence govern the intestinal epithelial global translational capacity
  • Beteiligte: Smit, Wouter Laurentius; Spaan, Claudia Nanette; Johannes de Boer, Ruben; Ramesh, Prashanthi; Martins Garcia, Tânia; Meijer, Bartolomeus Joannes; Vermeulen, Jacqueline Ludovicus Maria; Lezzerini, Marco; MacInnes, Alyson Winfried; Koster, Jan; Medema, Jan Paul; van den Brink, Gijs Robert; Muncan, Vanesa; Heijmans, Jarom
  • Erschienen: Proceedings of the National Academy of Sciences, 2020
  • Erschienen in: Proceedings of the National Academy of Sciences
  • Sprache: Englisch
  • DOI: 10.1073/pnas.1912772117
  • ISSN: 0027-8424; 1091-6490
  • Schlagwörter: Multidisciplinary
  • Entstehung:
  • Anmerkungen:
  • Beschreibung: <jats:title>Significance</jats:title> <jats:p> Deregulated global <jats:italic>mRNA</jats:italic> translation is a feature of various cancers and considered important in oncogenic transformation. In colorectal cancer (CRC), the role of the most common driver mutations in <jats:italic>APC</jats:italic> , <jats:italic>KRAS</jats:italic> , <jats:italic>SMAD4</jats:italic> , and <jats:italic>TP53</jats:italic> on the global translational capacity are incompletely understood. Here, using mouse and human intestinal organoids, we found that each mutation governs the global translational capacity of the epithelial cell. Global translation is linked to known oncogenic hallmarks, including cell proliferation and growth upon accumulation of these mutations, posing the translational apparatus as a potential therapeutic target in CRC. </jats:p>
  • Zugangsstatus: Freier Zugang