Recognition of the antigen-presenting molecule MR1 by a Vδ3+γδ T cell receptor

Medientyp: E-Artikel
Titel: Recognition of the antigen-presenting molecule MR1 by a Vδ3+γδ T cell receptor
Beteiligte: Rice, Michael T.; von Borstel, Anouk; Chevour, Priyanka; Awad, Wael; Howson, Lauren J.; Littler, Dene R.; Gherardin, Nicholas A.; Le Nours, Jérôme; Giles, Edward M.; Berry, Richard; Godfrey, Dale I.; Davey, Martin S.; Rossjohn, Jamie; Gully, Benjamin S.
Erschienen: Proceedings of the National Academy of Sciences, 2021
Erschienen in: Proceedings of the National Academy of Sciences
Sprache: Englisch
DOI: 10.1073/pnas.2110288118
ISSN: 0027-8424; 1091-6490
Schlagwörter: Multidisciplinary
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Beschreibung: <jats:title>Significance</jats:title><jats:p>Alongside αβ T cells and B cells, γδ T cells comprise a major component of the adaptive immune system, although a lack of bona fide ligands has hindered understanding of their function. γδ T cells are key mediators of epithelial immune surveillance and have a purported capacity for employing diverse ligand engagement mechanisms beyond the dogmas of conventional αβ T cell–human leukocyte antigen restriction. Here, we found blood- and gut-resident Vδ1/2<jats:sup>−</jats:sup>γδ T cells bound to MR1 tetramers in a metabolite-independent mechanism distinct from mucosal-associated invariant T cells and provide insight into a unique antibody-like MR1 recognition mode. This reshapes our understanding of the ligand recognition principles of γδ T cells and how they differ from αβ T cells.</jats:p>
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