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Manry, Jérémy;
Bastard, Paul;
Gervais, Adrian;
Le Voyer, Tom;
Rosain, Jérémie;
Philippot, Quentin;
Michailidis, Eleftherios;
Hoffmann, Hans-Heinrich;
Eto, Shohei;
Garcia-Prat, Marina;
Bizien, Lucy;
Parra-Martínez, Alba;
Yang, Rui;
Haljasmägi, Liis;
Migaud, Mélanie;
Särekannu, Karita;
Maslovskaja, Julia;
de Prost, Nicolas;
Tandjaoui-Lambiotte, Yacine;
Luyt, Charles-Edouard;
Amador-Borrero, Blanca;
Gaudet, Alexandre;
Poissy, Julien;
Morel, Pascal;
[...]
The risk of COVID-19 death is much greater and age dependent with type I IFN autoantibodies
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- Medientyp: E-Artikel
- Titel: The risk of COVID-19 death is much greater and age dependent with type I IFN autoantibodies
- Beteiligte: Manry, Jérémy; Bastard, Paul; Gervais, Adrian; Le Voyer, Tom; Rosain, Jérémie; Philippot, Quentin; Michailidis, Eleftherios; Hoffmann, Hans-Heinrich; Eto, Shohei; Garcia-Prat, Marina; Bizien, Lucy; Parra-Martínez, Alba; Yang, Rui; Haljasmägi, Liis; Migaud, Mélanie; Särekannu, Karita; Maslovskaja, Julia; de Prost, Nicolas; Tandjaoui-Lambiotte, Yacine; Luyt, Charles-Edouard; Amador-Borrero, Blanca; Gaudet, Alexandre; Poissy, Julien; Morel, Pascal; [...]
- Erschienen: Proceedings of the National Academy of Sciences, 2022
- Erschienen in: Proceedings of the National Academy of Sciences
- Sprache: Englisch
- DOI: 10.1073/pnas.2200413119
- ISSN: 1091-6490; 0027-8424
- Schlagwörter: Multidisciplinary
- Entstehung:
- Anmerkungen:
- Beschreibung: <jats:title>Significance</jats:title> <jats:p>There is growing evidence that preexisting autoantibodies neutralizing type I interferons (IFNs) are strong determinants of life-threatening COVID-19 pneumonia. It is important to estimate their quantitative impact on COVID-19 mortality upon SARS-CoV-2 infection, by age and sex, as both the prevalence of these autoantibodies and the risk of COVID-19 death increase with age and are higher in men. Using an unvaccinated sample of 1,261 deceased patients and 34,159 individuals from the general population, we found that autoantibodies against type I IFNs strongly increased the SARS-CoV-2 infection fatality rate at all ages, in both men and women. Autoantibodies against type I IFNs are strong and common predictors of life-threatening COVID-19. Testing for these autoantibodies should be considered in the general population.</jats:p>
- Zugangsstatus: Freier Zugang