• Medientyp: E-Artikel
  • Titel: Human CCR5high effector memory cells perform CNS parenchymal immune surveillance via GZMK-mediated transendothelial diapedesis
  • Beteiligte: Herich, Sebastian; Schneider-Hohendorf, Tilman; Rohlmann, Astrid; Khaleghi Ghadiri, Maryam; Schulte-Mecklenbeck, Andreas; Zondler, Lisa; Janoschka, Claudia; Ostkamp, Patrick; Richter, Jannis; Breuer, Johanna; Dimitrov, Stoyan; Rammensee, Hans-Georg; Grauer, Oliver M; Klotz, Luisa; Gross, Catharina C; Stummer, Walter; Missler, Markus; Zarbock, Alexander; Vestweber, Dietmar; Wiendl, Heinz; Schwab, Nicholas
  • Erschienen: Oxford University Press (OUP), 2019
  • Erschienen in: Brain
  • Sprache: Englisch
  • DOI: 10.1093/brain/awz301
  • ISSN: 0006-8950; 1460-2156
  • Schlagwörter: Neurology (clinical)
  • Entstehung:
  • Anmerkungen:
  • Beschreibung: <jats:p>Specific immune-cell populations patrol the CNS in search of pathogens and tumours. Herich et al. identify CD4+ CCR5high GzmK+ effector-memory cells as a brain-surveilling subpopulation capable of crossing the uninflamed blood-brain barrier, and reveal alterations in this population in HIV+ patients with neurological symptoms and in patients with multiple sclerosis.</jats:p>
  • Zugangsstatus: Freier Zugang