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Euser, Sjoerd; Aronson, Sem; Manders, Irene; van Lelyveld, Steven; Herpers, Bjorn; Sinnige, Jan; Kalpoe, Jayant; van Gemeren, Claudia; Snijders, Dominic; Jansen, Ruud; Schuurmans Stekhoven, Sophie; van Houten, Marlies; Lede, Ivar; Cohen Stuart, James; Slijkerman Megelink, Fred; Kapteijns, Erik; den Boer, Jeroen; Sanders, Elisabeth; Wagemakers, Alex; Souverein, Dennis

SARS-CoV-2 viral-load distribution reveals that viral loads increase with age: a retrospective cross-sectional cohort study

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  • Medientyp: E-Artikel
  • Titel: SARS-CoV-2 viral-load distribution reveals that viral loads increase with age: a retrospective cross-sectional cohort study
  • Beteiligte: Euser, Sjoerd; Aronson, Sem; Manders, Irene; van Lelyveld, Steven; Herpers, Bjorn; Sinnige, Jan; Kalpoe, Jayant; van Gemeren, Claudia; Snijders, Dominic; Jansen, Ruud; Schuurmans Stekhoven, Sophie; van Houten, Marlies; Lede, Ivar; Cohen Stuart, James; Slijkerman Megelink, Fred; Kapteijns, Erik; den Boer, Jeroen; Sanders, Elisabeth; Wagemakers, Alex; Souverein, Dennis
  • Erschienen: Oxford University Press (OUP), 2022
  • Erschienen in: International Journal of Epidemiology
  • Sprache: Englisch
  • DOI: 10.1093/ije/dyab145
  • ISSN: 0300-5771; 1464-3685
  • Schlagwörter: General Medicine ; Epidemiology
  • Entstehung:
  • Anmerkungen:
  • Beschreibung: <jats:title>Abstract</jats:title> <jats:sec> <jats:title>Background</jats:title> <jats:p>Describing the SARS-CoV-2 viral-load distribution in different patient groups and age categories.</jats:p> </jats:sec> <jats:sec> <jats:title>Methods</jats:title> <jats:p>All results from first nasopharyngeal (NP) and oropharyngeal (OP) swabs from unique patients tested via SARS-CoV-2 reverse transcriptase polymerase chain reaction (RT-PCR) collected between 1 January and 1 December 2020 predominantly in the Public Health Services regions Kennemerland and Hollands Noorden, province of North Holland, the Netherlands, were included in this study. SARS-CoV-2 PCR crossing-point (Cp)-values were used to estimate viral loads.</jats:p> </jats:sec> <jats:sec> <jats:title>Results</jats:title> <jats:p>In total, 278 455 unique patients were tested, of whom 9.1% (n = 25.374) were SARS-CoV-2-positive. PCRs performed by Public Health Services (n = 211 914), in which sampling and inclusion were uniform, revealed a clear relation between age and SARS-CoV-2 viral load, with especially children aged &amp;lt;12 years showing lower viral loads than adults (β: –0.03, 95% confidence interval: –0.03 to –0.02, p &amp;lt; 0.001), independently of sex and/or symptom duration. Interestingly, the median Cp-values between the &amp;gt;79- and &amp;lt;12-year-old populations differed by more than four PCR cycles, suggesting an ∼16-fold difference in viral load. In addition, the proportion of children aged &amp;lt;12 years with a low load (Cp-value &amp;gt;30) was higher compared with other patients (31.1% vs 17.2%, p-value &amp;lt; 0.001).</jats:p> </jats:sec> <jats:sec> <jats:title>Conclusions</jats:title> <jats:p>In patients tested by Public Health Services, SARS-CoV-2 viral load increases with age. Further studies should elucidate whether the lower viral load in children is indeed related to their suggested limited role in SARS-CoV-2 transmission. Moreover, as rapid antigen tests are less sensitive than PCR, these results suggest that SARS-CoV-2 antigen tests have lower sensitivity in children than in adults.</jats:p> </jats:sec>
  • Zugangsstatus: Freier Zugang