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Manning, Jessica E; Chea, Sophana; Parker, Daniel M; Bohl, Jennifer A; Lay, Sreyngim; Mateja, Allyson; Man, Somnang; Nhek, Sreynik; Ponce, Aiyana; Sreng, Sokunthea; Kong, Dara; Kimsan, Soun; Meneses, Claudio; Fay, Michael P; Suon, Seila; Huy, Rekol; Lon, Chanthap; Leang, Rithea; Oliveira, Fabiano

Development of Inapparent Dengue Associated With Increased Antibody Levels to Aedes aegypti Salivary Proteins: A Longitudinal Dengue Cohort in Cambodia

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  • Medientyp: E-Artikel
  • Titel: Development of Inapparent Dengue Associated With Increased Antibody Levels to Aedes aegypti Salivary Proteins: A Longitudinal Dengue Cohort in Cambodia
  • Beteiligte: Manning, Jessica E; Chea, Sophana; Parker, Daniel M; Bohl, Jennifer A; Lay, Sreyngim; Mateja, Allyson; Man, Somnang; Nhek, Sreynik; Ponce, Aiyana; Sreng, Sokunthea; Kong, Dara; Kimsan, Soun; Meneses, Claudio; Fay, Michael P; Suon, Seila; Huy, Rekol; Lon, Chanthap; Leang, Rithea; Oliveira, Fabiano
  • Erschienen: Oxford University Press (OUP), 2022
  • Erschienen in: The Journal of Infectious Diseases
  • Sprache: Englisch
  • DOI: 10.1093/infdis/jiab541
  • ISSN: 0022-1899; 1537-6613
  • Schlagwörter: Infectious Diseases ; Immunology and Allergy
  • Entstehung:
  • Anmerkungen:
  • Beschreibung: <jats:title>Abstract</jats:title> <jats:sec> <jats:title>Background</jats:title> <jats:p>We established the first prospective cohort to understand how infection with dengue virus is influenced by vector-specific determinants such as humoral immunity to Aedes aegypti salivary proteins.</jats:p> </jats:sec> <jats:sec> <jats:title>Methods</jats:title> <jats:p>Children aged 2–9 years were enrolled in the PAGODAS (Pediatric Assessment Group of Dengue and Aedes Saliva) cohort with informed consent by their guardians. Children were followed semi-annually for antibodies to dengue and to proteins in Ae. aegypti salivary gland homogenate using enzyme-linked immunosorbent assays and dengue-specific neutralization titers. Children presented with fever at any time for dengue testing.</jats:p> </jats:sec> <jats:sec> <jats:title>Results</jats:title> <jats:p>From 13 July to 30 August 2018, we enrolled 771 children. At baseline, 22% (173/770) had evidence of neutralizing antibodies to 1 or more dengue serotypes. By April 2020, 51 children had symptomatic dengue while 148 dengue-naive children had inapparent dengue defined by neutralization assays. In a multivariate model, individuals with higher antibodies to Ae. aegypti salivary proteins were 1.5 times more likely to have dengue infection (hazard ratio [HR], 1.47 [95% confidence interval {CI}, 1.05–2.06]; P = .02), particularly individuals with inapparent dengue (HR, 1.64 [95% CI, 1.12–2.41]; P = .01).</jats:p> </jats:sec> <jats:sec> <jats:title>Conclusions</jats:title> <jats:p>High levels of seropositivity to Ae. aegypti salivary proteins are associated with future development of dengue infection, primarily inapparent, in dengue-naive Cambodian children.</jats:p> </jats:sec> <jats:sec> <jats:title>Clinical Trials Registration</jats:title> <jats:p>NCT03534245</jats:p> </jats:sec>
  • Zugangsstatus: Freier Zugang