Postacute sequelae and adaptive immune responses in people with HIV recovering from SARS-COV-2 infection

Medientyp: E-Artikel
Titel: Postacute sequelae and adaptive immune responses in people with HIV recovering from SARS-COV-2 infection
Beteiligte: Peluso, Michael J.; Spinelli, Matthew A.; Deveau, Tyler-Marie; Forman, Carrie A.; Munter, Sadie E.; Mathur, Sujata; Tang, Alex F.; Lu, Scott; Goldberg, Sarah A.; Arreguin, Mireya I.; Hoh, Rebecca; Tai, Viva; Chen, Jessica Y.; Martinez, Enrique O.; Yee, Brandon C.; Chenna, Ahmed; Winslow, John W.; Petropoulos, Christos J.; Sette, Alessandro; Weiskopf, Daniella; Kumar, Nitasha; Lynch, Kara L.; Hunt, Peter W.; Durstenfeld, Matthew S.; [...]
Erschienen: Ovid Technologies (Wolters Kluwer Health), 2022
Erschienen in: AIDS
Sprache: Englisch
DOI: 10.1097/qad.0000000000003338
ISSN: 0269-9370; 1473-5571
Schlagwörter: Infectious Diseases ; Immunology ; Immunology and Allergy
Entstehung:
Anmerkungen:
Beschreibung: <jats:sec> <jats:title>Background:</jats:title> <jats:p>Limited data are available on the long-term clinical and immunologic consequences of SARS-CoV-2 infection in people with HIV (PWH).</jats:p> </jats:sec> <jats:sec> <jats:title>Methods:</jats:title> <jats:p>We measured SARS-CoV-2-specific humoral and cellular responses in people with and without HIV recovering from COVID-19 (<jats:italic toggle="yes">n</jats:italic> = 39 and <jats:italic toggle="yes">n</jats:italic> = 43, respectively) using binding antibody, surrogate virus neutralization, intracellular cytokine staining, and inflammatory marker assays. We identified individuals experiencing postacute sequelae of SARS-CoV-2 infection (PASC) and evaluated immunologic parameters. We used linear regression and generalized linear models to examine differences by HIV status in the magnitude of inflammatory and virus-specific antibody and T-cell responses, as well as differences in the prevalence of PASC.</jats:p> </jats:sec> <jats:sec> <jats:title>Results:</jats:title> <jats:p>Among PWH, we found broadly similar SARS-CoV-2-specific antibody and T-cell responses as compared with a well matched group of HIV-negative individuals. PWH had 70% lower relative levels of SARS-CoV-2-specific memory CD8<jats:sup>+</jats:sup> T cells (<jats:italic toggle="yes">P</jats:italic> = 0.007) and 53% higher relative levels of PD-1+ SARS-CoV-2-specific CD4<jats:sup>+</jats:sup> T cells (<jats:italic toggle="yes">P</jats:italic> = 0.007). Higher CD4<jats:sup>+</jats:sup>/CD8<jats:sup>+</jats:sup> ratio was associated with lower PD-1 expression on SARS-CoV-2-specific CD8<jats:sup>+</jats:sup> T cells (0.34-fold effect, <jats:italic toggle="yes">P</jats:italic> = 0.02). HIV status was strongly associated with PASC (odds ratio 4.01, <jats:italic toggle="yes">P</jats:italic> = 0.008), and levels of certain inflammatory markers (IL-6, TNF-alpha, and IP-10) were associated with persistent symptoms.</jats:p> </jats:sec> <jats:sec> <jats:title>Conclusion:</jats:title> <jats:p>We identified potentially important differences in SARS-CoV-2-specific CD4<jats:sup>+</jats:sup> and CD8<jats:sup>+</jats:sup> T cells in PWH and HIV-negative participants that might have implications for long-term immunity conferred by natural infection. HIV status strongly predicted the presence of PASC. Larger and more detailed studies of PASC in PWH are urgently needed.</jats:p> </jats:sec>
Zugangsstatus: Freier Zugang

Nur in Feld suchen:

Zuletzt gesuchte Begriffe: