Rathke, Hendrik;
Fuxius, Stefan;
Giesel, Frederik L.;
Lindner, Thomas;
Debus, Jürgen;
Haberkorn, Uwe;
Kratochwil, Clemens
Two Tumors, One Target : Preliminary Experience With 90Y-FAPI Therapy in a Patient With Metastasized Breast and Colorectal Cancer
: Preliminary Experience With 90Y-FAPI Therapy in a Patient With Metastasized Breast and Colorectal Cancer
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Medientyp:
E-Artikel
Titel:
Two Tumors, One Target : Preliminary Experience With 90Y-FAPI Therapy in a Patient With Metastasized Breast and Colorectal Cancer
:
Preliminary Experience With 90Y-FAPI Therapy in a Patient With Metastasized Breast and Colorectal Cancer
Beteiligte:
Rathke, Hendrik;
Fuxius, Stefan;
Giesel, Frederik L.;
Lindner, Thomas;
Debus, Jürgen;
Haberkorn, Uwe;
Kratochwil, Clemens
Beschreibung:
<jats:title>Abstract</jats:title>
<jats:p>We report a patient with breast cancer (BC) diagnosed in 2009 with metachronous lymph node, liver, and bone metastases. In 2017, colorectal cancer with peritoneal metastases was additionally diagnosed and treated with 8 cycles of capecitabine due to its antitumor activity against both malignancies. At progression of both diseases, FAPI PET/CT demonstrated positive tumor targeting in BC-related metastases and colorectal cancer–related metastases. The patient received an experimental therapy with <jats:sup>90</jats:sup>Y-FAPI46. Although there was similar tracer uptake in the PET/CT, the radioligand therapy resulted in mixed response with disappearance of peritoneal metastases but minor efficacy treating the BC-related metastases.</jats:p>