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Werner, Anke; Seifert, Philipp; Theis, Bernhard; Freesmeyer, Martin; Leder, Theresa

Image-Guided Fine-Needle Aspiration Cytology for BRCA Mutation Assessment of PSMA-Positive Lymph Node Metastases in a Patient With Metastatic Castration-Resistant Prostate Cancer

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  • Medientyp: E-Artikel
  • Titel: Image-Guided Fine-Needle Aspiration Cytology for BRCA Mutation Assessment of PSMA-Positive Lymph Node Metastases in a Patient With Metastatic Castration-Resistant Prostate Cancer
  • Beteiligte: Werner, Anke; Seifert, Philipp; Theis, Bernhard; Freesmeyer, Martin; Leder, Theresa
  • Erschienen: Ovid Technologies (Wolters Kluwer Health), 2023
  • Erschienen in: Clinical Nuclear Medicine
  • Sprache: Englisch
  • DOI: 10.1097/rlu.0000000000004879
  • ISSN: 1536-0229; 0363-9762
  • Schlagwörter: Radiology, Nuclear Medicine and imaging ; General Medicine
  • Entstehung:
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  • Beschreibung: <jats:title>Abstract</jats:title> <jats:p>A 64-year-old man with metastatic castration-resistant prostate cancer presented for prostate-specific membrane antigen (PSMA) PET/CT in preparation for <jats:sup>177</jats:sup>Lu-PSMA radioligand therapy. For precedent <jats:italic toggle="yes">BRCA</jats:italic> mutation assessment, fine-needle aspiration cytology of 2 PSMA-positive lymph node metastases was conducted. The acquired material was suitable for next-generation sequencing-based gene panel diagnostics and did not show a <jats:italic toggle="yes">BRCA1</jats:italic>/<jats:italic toggle="yes">2</jats:italic> mutation, thus PSMA radioligand therapy was initiated. Fine-needle aspiration cytology of lymph node metastases may be a viable option in evaluating further therapeutic alternatives.</jats:p>