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Medientyp:
E-Artikel
Titel:
Insights into the chemistry and therapeutic potential of acrylonitrile derivatives
Beteiligte:
Unsal Tan, Oya;
Zengin, Merve
Erschienen:
Wiley, 2022
Erschienen in:Archiv der Pharmazie
Sprache:
Englisch
DOI:
10.1002/ardp.202100383
ISSN:
0365-6233;
1521-4184
Entstehung:
Anmerkungen:
Beschreibung:
<jats:title>Abstract</jats:title><jats:p>Acrylonitrile is a fascinating scaffold widely found in many natural products, drugs, and drug candidates with various biological activities. Several drug molecules such as entacapone, rilpivirine, teriflunomide, and so forth, bearing an acrylonitrile moiety have been marketed. In this review, diverse synthetic strategies for constructing desired acrylonitriles are discussed, and the different biological activities and medicinal significance of various acrylonitrile derivatives are critically evaluated. The information gathered is expected to provide rational guidance for the development of clinically useful agents from acrylonitriles.</jats:p>