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Capellini, Terence D.; Handschuh, Karen; Quintana, Laura; Ferretti, Elisabetta; Di Giacomo, Giuseppina; Fantini, Sebastian; Vaccari, Giulia; Clarke, Shoa L.; Wenger, Aaron M.; Bejerano, Gill; Sharpe, James; Zappavigna, Vincenzo; Selleri, Licia

Control of pelvic girdle development by genes of the Pbx family and Emx2

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  • Medientyp: E-Artikel
  • Titel: Control of pelvic girdle development by genes of the Pbx family and Emx2
  • Beteiligte: Capellini, Terence D.; Handschuh, Karen; Quintana, Laura; Ferretti, Elisabetta; Di Giacomo, Giuseppina; Fantini, Sebastian; Vaccari, Giulia; Clarke, Shoa L.; Wenger, Aaron M.; Bejerano, Gill; Sharpe, James; Zappavigna, Vincenzo; Selleri, Licia
  • Erschienen: Wiley, 2011
  • Erschienen in: Developmental Dynamics
  • Sprache: Englisch
  • DOI: 10.1002/dvdy.22617
  • ISSN: 1058-8388; 1097-0177
  • Entstehung:
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  • Beschreibung: <jats:title>Abstract</jats:title><jats:p>Genes expressed in the somatopleuric mesoderm, the embryonic domain giving rise to the vertebrate pelvis, appear important for pelvic girdle formation. Among such genes, Pbx family members and <jats:italic>Emx2</jats:italic> were found to genetically interact in hindlimb and pectoral girdle formation. Here, we generated compound mutant embryos carrying combinations of mutated alleles for <jats:italic>Pbx1</jats:italic>, <jats:italic>Pbx2</jats:italic>, and <jats:italic>Pbx3</jats:italic>, as well as <jats:italic>Pbx1</jats:italic> and <jats:italic>Emx2</jats:italic>, to examine potential genetic interactions during pelvic development. Indeed, Pbx genes share overlapping functions and <jats:italic>Pbx1</jats:italic> and <jats:italic>Emx2</jats:italic> genetically interact in pelvic formation. We show that, in compound <jats:italic>Pbx1;Pbx2</jats:italic> and <jats:italic>Pbx1;Emx2</jats:italic> mutants, pelvic mesenchymal condensation is markedly perturbed, indicative of an upstream control by these homeoproteins. We establish that expression of <jats:italic>Tbx15</jats:italic>, <jats:italic>Prrx1</jats:italic>, and <jats:italic>Pax1</jats:italic>, among other genes involved in the specification and development of select pelvic structures, is altered in our compound mutants. Lastly, we identify potential Pbx1‐Emx2–regulated enhancers for <jats:italic>Tbx15</jats:italic>, <jats:italic>Prrx1</jats:italic>, and <jats:italic>Pax1</jats:italic>, using bioinformatics analyses. Developmental Dynamics 240:1173–1189, 2011. © 2011 Wiley‐Liss, Inc.</jats:p>
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