> Merkliste Sie können Bookmarks mittels Listen verwalten, loggen Sie sich dafür bitte in Ihr SLUB Benutzerkonto ein.
Medientyp: E-Artikel Titel: Microstructural disassembly of calcium phosphates Beteiligte: Wang, Haibo; Lee, Jong‐Kook; Moursi, Amr M.; Anderson, David; Winnard, Phillip; Powell, Heather; Lannutti, John Erschienen: Wiley, 2004 Erschienen in: Journal of Biomedical Materials Research Part A Sprache: Englisch DOI: 10.1002/jbm.a.20056 ISSN: 1549-3296; 1552-4965 Schlagwörter: Metals and Alloys ; Biomedical Engineering ; Biomaterials ; Ceramics and Composites Entstehung: Anmerkungen: Beschreibung: <jats:title>Abstract</jats:title><jats:p>Microstructural factors may play a role in the osseointegration of calcium phosphates. In this paper, direct microstructural interactions between crystalline calcium phosphates and the biological milieu are reported. Degradation via exposure to osteoblast culture closely resembles <jats:italic>in vivo</jats:italic> interactions with subcutaneous tissues in a bovine model at early time periods. That these interactions were common to both experiments constitutes one of the few known examples of <jats:italic>in vitro</jats:italic>–<jats:italic>in vivo</jats:italic> correspondence. Interestingly, the degradation of phase pure hydroxyapatite (HA) <jats:italic>in vitro</jats:italic> was more rapid than that of biphasic HA <jats:italic>in vivo</jats:italic>. In both cases, grain extraction/pullout was frequently observed. This suggests a connection to smaller‐scale observations of epitaxial CHA nucleation and growth on pre‐existing HA grains. A microstructure in which the grain boundary is dissolving/corroding can apparently be disassembled by forces transmitted through biological structures. These observations are distinct from those of simple non‐biological solutions and prove that biological environments can interact with the material beneath the ceramic‐cell/ceramic‐tissue interface. Many often ignored microstructural factors—grain size, shape, grain boundary strength and the presence of impurity phases—may in fact control degradation. We also suggest that even relatively modest initial grain sizes will, in combination with the mild/absent foreign body response to calcium phosphates, result in lengthy <jats:italic>in vivo</jats:italic> particle resistence. © 2003 Wiley Periodicals, Inc. J Biomed Mater Res 68A: 61–70, 2004</jats:p>