Carrier‐effect on palladium‐catalyzed, nucleophilic 18F‐fluorination of aryl triflates

Medientyp: E-Artikel
Titel: Carrier‐effect on palladium‐catalyzed, nucleophilic 18F‐fluorination of aryl triflates
Beteiligte: Cardinale, Jens; Ermert, Johannes; Kügler, Fabian; Helfer, Andreas; Brandt, Marie R.; Coenen, Heinz H.
Erschienen: Wiley, 2012
Erschienen in: Journal of Labelled Compounds and Radiopharmaceuticals
Sprache: Englisch
DOI: 10.1002/jlcr.2973
ISSN: 0362-4803; 1099-1344
Schlagwörter: Organic Chemistry ; Spectroscopy ; Drug Discovery ; Radiology, Nuclear Medicine and imaging ; Biochemistry ; Analytical Chemistry
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Beschreibung: <jats:p>A recently published palladium‐catalyzed preparation of fluoroarenes starting from caesium fluoride attracted interest as a new alternative for radiofluorination. To test this method, a suitable protocol for the synthesis of 4‐[<jats:sup>18</jats:sup>F]fluorotoluene and 1‐[<jats:sup>18</jats:sup>F]fluoronaphthalene as model systems has been developed. The possibility to perform the reaction under no‐carrier‐added condition was of special interest. It was found out, however, that the reaction requires the presence of carrier, thus limiting the method to syntheses of radiotracers with low specific activity. Copyright © 2012 John Wiley & Sons, Ltd.</jats:p>

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