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Otazo, Ricardo; Mueller, Bryon; Ugurbil, Kamil; Wald, Lawrence; Posse, Stefan

Signal‐to‐noise ratio and spectral linewidth improvements between 1.5 and 7 Tesla in proton echo‐planar spectroscopic imaging

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  • Medientyp: E-Artikel
  • Titel: Signal‐to‐noise ratio and spectral linewidth improvements between 1.5 and 7 Tesla in proton echo‐planar spectroscopic imaging
  • Beteiligte: Otazo, Ricardo; Mueller, Bryon; Ugurbil, Kamil; Wald, Lawrence; Posse, Stefan
  • Erschienen: Wiley, 2006
  • Erschienen in: Magnetic Resonance in Medicine
  • Sprache: Englisch
  • DOI: 10.1002/mrm.21067
  • ISSN: 0740-3194; 1522-2594
  • Schlagwörter: Radiology, Nuclear Medicine and imaging
  • Entstehung:
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  • Beschreibung: <jats:title>Abstract</jats:title><jats:p>This study characterizes gains in sensitivity and spectral resolution of proton echo‐planar spectroscopic imaging (PEPSI) with increasing magnetic field strength (<jats:italic>B</jats:italic><jats:sub>0</jats:sub>). Signal‐to‐noise ratio (SNR) per unit volume and unit time, and intrinsic linewidth (LW) of N‐acetyl‐aspartate (NAA), creatine (Cr), and choline (Cho) were measured with PEPSI at 1.5, 3, 4, and 7 Tesla on scanners that shared a similar software and hardware platform, using circularly polarized (CP) and eight‐channel phased‐array (PA) head coils. Data were corrected for relaxation effects and processed with a time‐domain matched filter (MF) adapted to each <jats:italic>B</jats:italic><jats:sub>0</jats:sub>. The SNR and LW measured with PEPSI were very similar to those measured with conventional point‐resolved spectroscopy (PRESS) SI. Measurements with the CP coil demonstrated a nearly linear SNR gain with respect to <jats:italic>B</jats:italic><jats:sub>0</jats:sub> in central brain regions. For the PA coil, the SNR–<jats:italic>B</jats:italic><jats:sub>0</jats:sub> relationship was less than linear, but there was a substantial SNR increase in comparison to the CP coil. The LW in units of ppm decreased with <jats:italic>B</jats:italic><jats:sub>0</jats:sub>, resulting in improved spectral resolution. These studies using PEPSI demonstrated linear gains in SNR with respect to <jats:italic>B</jats:italic><jats:sub>0</jats:sub>, consistent with theoretical expectations, and a decrease in ppm LW with increasing <jats:italic>B</jats:italic><jats:sub>0</jats:sub>. Magn Reson Med, 2006. © 2006 Wiley‐Liss, Inc.</jats:p>