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Medientyp: E-Artikel Titel: 3D myocardial T1 mapping at 3T using variable flip angle method: Pilot study Beteiligte: Clique, Hélène; Cheng, Hai‐Ling Margaret; Marie, Pierre‐Yves; Felblinger, Jacques; Beaumont, Marine Erschienen: Wiley, 2014 Erschienen in: Magnetic Resonance in Medicine Sprache: Englisch DOI: 10.1002/mrm.24688 ISSN: 0740-3194; 1522-2594 Schlagwörter: Radiology, Nuclear Medicine and imaging Entstehung: Anmerkungen: Beschreibung: <jats:sec><jats:title>Purpose</jats:title><jats:p>Myocardial <jats:italic>T</jats:italic><jats:sub>1</jats:sub> mapping is an emerging technique that could improve cardiovascular magnetic resonance diagnostic accuracy. In this study, a variable flip angle approach with B<jats:sub>1</jats:sub> correction is proposed at 3T on the myocardium, employing standard 3D spoiled fast gradient echo and echo planar imaging sequences.</jats:p></jats:sec><jats:sec><jats:title>Methods</jats:title><jats:p>The method was tested on phantoms to determine the set of standard 3D spoiled fast gradient echo angles adapted to myocardial <jats:italic>T</jats:italic><jats:sub>1</jats:sub> measurements and was compared to the inversion‐recovery spin‐echo reference <jats:italic>T</jats:italic><jats:sub>1</jats:sub> method. Seven volunteers underwent magnetic imaging resonance to acquire myocardial <jats:italic>T</jats:italic><jats:sub>1</jats:sub> maps and <jats:italic>T</jats:italic><jats:sub>1</jats:sub> values of the human heart.</jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p>This original method demonstrated good reproducibility in phantoms and a significant correlation between variable flip angle <jats:italic>T</jats:italic><jats:sub>1</jats:sub> values and reference inversion‐recovery spin‐echo <jats:italic>T</jats:italic><jats:sub>1</jats:sub> values. It yielded myocardial <jats:italic>T</jats:italic><jats:sub>1</jats:sub> values consistent with expected <jats:italic>T</jats:italic><jats:sub>1</jats:sub> and an increasing homogenization of myocardial segments owing to <jats:italic>B</jats:italic><jats:sub>1</jats:sub> correction. The mean myocardial <jats:italic>T</jats:italic><jats:sub>1</jats:sub> value was 1341 ± 42 ms.</jats:p></jats:sec><jats:sec><jats:title>Conclusion</jats:title><jats:p>Myocardial 3D <jats:italic>T</jats:italic><jats:sub>1</jats:sub> mapping using the variable flip angle approach can potentially be useful for evaluating fibrosis on the entire myocardium using a standard clinical sequence. Magn Reson Med 71:823–829, 2014. © 2013 Wiley Periodicals, Inc.</jats:p></jats:sec>