Beschreibung:
<jats:p>Noninvasively assessing tissue potassium concentrations (TPCs) using potassium magnetic resonance imaging (<jats:sup>39</jats:sup>K MRI) could give valuable information on physiological processes connected to various pathologies. However, because of inherently low <jats:sup>39</jats:sup>K MR image resolution and strong signal blurring, a reliable measurement of the TPC is challenging. The aim of this work was to investigate the feasibility of a muscle‐specific TPC determination with a focus on the influence of a varying residual quadrupolar interaction in human lower leg muscles. The quantification accuracy of a muscle‐specific TPC determination was first assessed using simulated <jats:sup>39</jats:sup>K MRI data. In vivo <jats:sup>39</jats:sup>K and corresponding sodium (<jats:sup>23</jats:sup>Na) MRI data of healthy lower leg muscles (n = 14, seven females) were acquired on a 7‐T MR system using a double‐resonant <jats:sup>23</jats:sup>Na/<jats:sup>39</jats:sup>K birdcage Tx/Rx RF coil. Additional <jats:sup>1</jats:sup>H MR images were acquired on a 3‐T MR system and used for tissue segmentation. Quantification of TPC was performed after a region‐based partial volume correction (PVC) using five external reference phantoms. Simulations not only underlined the importance of PVC for correctly assessing muscle‐specific TPC values, but also revealed the strong impact of a varying residual quadrupolar interaction between different muscle regions on the measured TPC. Using <jats:sup>39</jats:sup>K T<jats:sub>2</jats:sub><jats:sup>*</jats:sup> decay curves, we found significantly higher residual quadrupolar interaction in tibialis anterior muscle (TA; ω<jats:sub>q</jats:sub> = 194 ± 28 Hz) compared with gastrocnemius muscle (medial/lateral head, GM/GL; ω<jats:sub>q</jats:sub> = 151 ± 25 Hz) and soleus muscle (SOL; ω<jats:sub>q</jats:sub> = 102 ± 32 Hz). If considered in the PVC, TPC in individual muscles was similar (TPC = 98 ± 11/96 ± 14/99 ± 8/100 ± 12 mM in GM/GL/SOL/TA). Comparison with tissue sodium concentrations suggested that residual quadrupolar interactions might also influence the <jats:sup>23</jats:sup>Na MRI signal of lower leg muscles. A TPC determination of individual lower leg muscles is feasible and can therefore be applied in future studies. Considering a varying residual quadrupolar interaction for PVC of <jats:sup>39</jats:sup>K MRI data is essential to reliably assess potassium concentrations in individual muscles.</jats:p>