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Espiritu, Adrian I.; Sy, Marie Charmaine C.; Anlacan, Veeda Michelle M.; Jamora, Roland Dominic G.; Macalintal, Corina Maria Socorro A.; Robles, Joanne B.; Cataniag, Paulo L.; Flores, Manolo Kristoffer C.; Tangcuangco-Trinidad, Noreen Jhoanna C.; Juangco, Dan Neftalie A.; Paas, Giuliani Renz G.; Chua, Audrey Marie U.; Estrada, Valmarie S.; Mejia, Philip Rico P.; Reyes, Therese Franz B.; Cañete, Maria Teresa A.; Zapata, Ferdinand Renfred A.; Castillo, Franko Eugenio B.; Esagunde, Romulo U.; Gantioque, Jean B.; Abbariao, Maritoni C.; Acebuque, Geramie M.; Corral, Evram V.; Escasura, Marian Irene C.; [...]

COVID-19 outcomes of 10,881 patients: retrospective study of neurological symptoms and associated manifestations (Philippine CORONA Study)

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  • Medientyp: E-Artikel
  • Titel: COVID-19 outcomes of 10,881 patients: retrospective study of neurological symptoms and associated manifestations (Philippine CORONA Study)
  • Beteiligte: Espiritu, Adrian I.; Sy, Marie Charmaine C.; Anlacan, Veeda Michelle M.; Jamora, Roland Dominic G.; Macalintal, Corina Maria Socorro A.; Robles, Joanne B.; Cataniag, Paulo L.; Flores, Manolo Kristoffer C.; Tangcuangco-Trinidad, Noreen Jhoanna C.; Juangco, Dan Neftalie A.; Paas, Giuliani Renz G.; Chua, Audrey Marie U.; Estrada, Valmarie S.; Mejia, Philip Rico P.; Reyes, Therese Franz B.; Cañete, Maria Teresa A.; Zapata, Ferdinand Renfred A.; Castillo, Franko Eugenio B.; Esagunde, Romulo U.; Gantioque, Jean B.; Abbariao, Maritoni C.; Acebuque, Geramie M.; Corral, Evram V.; Escasura, Marian Irene C.; [...]
  • Erschienen: Springer Science and Business Media LLC, 2021
  • Erschienen in: Journal of Neural Transmission
  • Sprache: Englisch
  • DOI: 10.1007/s00702-021-02400-5
  • ISSN: 0300-9564; 1435-1463
  • Schlagwörter: Biological Psychiatry ; Psychiatry and Mental health ; Neurology (clinical) ; Neurology
  • Entstehung:
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  • Beschreibung: <jats:title>Abstract</jats:title><jats:p>Our study aimed to determine the effects of new-onset neurological symptoms (NNS) on clinically relevant outcomes in hospitalized patients with COVID-19 infection. We conducted a nationwide, comparative, retrospective, cohort study among adult, hospitalized COVID-19 patients involving 37 hospital sites from various regions in the Philippines. We included a total of 10,881 patients with confirmed COVID-19 infection (2008 had NNS while 8873 did not have NNS). The adjusted hazard ratios (aHRs) for mortality among the mild and severe cases were significantly higher by 1.660 (95% CI 1.132–2.435) and by 1.352 (95% CI 1.042–1.752), respectively, in the NNS group compared to those in the non-NNS group. The aHRs for respiratory failure in the NNS group were significantly increased by 1.914 (95% CI 1.346–2.722), by 1.614 (95% CI 1.260–2.068), and by 1.234 (95% CI 1.089–1.398) among the mild, severe, and critical cases, respectively. The aHRs for ICU admission in the NNS group were still significantly higher by 1.973 (95% CI 1.457–2.673) and by 1.831 (95% CI 1.506–2.226) among the mild and severe cases, respectively. Patients who had NNS were not significantly associated with a longer duration of ventilator dependence (adjusted odds ratio (aOR) 0.954, 95% CI 0.772–1.179), longer ICU stay (aOR 0.983, 95% CI 0.772–1.252) and longer hospital admission (aOR 1.045, 95% CI 0.947–1.153). The presence of NNS significantly increases the risk of mortality, respiratory failure and ICU admission among COVID-19 patients. Registration and associated protocol publication: ClinicalTrials.gov website (NCT04386083); Espiritu AI, Sy MCC, Anlacan VMM, Jamora RDG. The Philippine COVID-19 Outcomes: a Retrospective study Of Neurological manifestations and Associated symptoms (The Philippine CORONA study): a protocol study. BMJ Open. 2020;10:e040944.</jats:p>