Beschreibung:
<jats:title>Abstract</jats:title><jats:sec><jats:title>Introduction</jats:title><jats:p>Selective internal radiotherapy (SIRT) with yttrium-90 (Y-90) is an intra-arterial therapy for hepatic malignancy in patients who are unsuitable for surgical resection. This treatment is considered palliative, although some patients can demonstrate a response that is adequate to facilitate surgical resection with curative intent.</jats:p></jats:sec><jats:sec><jats:title>Methods</jats:title><jats:p>All patients who underwent liver resection post SIRT were reviewed. Data gathered included patient demographics, tumor type, surgical details, and post-operative outcomes.</jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p>Twelve patients underwent SIRT followed by liver resection (7 males and 5 females). Pathologies were hepatocellular carcinoma (<jats:italic>n</jats:italic> = 5), metastatic colorectal cancer (<jats:italic>n</jats:italic> = 5), and neuroendocrine tumor (<jats:italic>n</jats:italic> = 2). Lesional response (size, volume, and RECIST (response evaluation criteria in solid tumors)) was calculated and where appropriate functional liver remnant (FLR) is presented. Mean FLR increase was 264cm<jats:sup>3</jats:sup>(range − 123 to 909), and all cases demonstrated a partial response according to RECIST with a mean largest lesion volume reduction of 475cm<jats:sup>3</jats:sup>(range 14–1632). No post-SIRT complications were noted. Hepatectomy occurred at a mean of 322 days from SIRT treatment. Ninety-day morbidity was 67% (<jats:italic>n</jats:italic> = 6), complications post-surgery were analyzed according to the Clavien-Dindo classification scale; a total of 15 events occurred in 6 patients. Ninety-day mortality of 11% (<jats:italic>n</jats:italic> = 1).</jats:p></jats:sec><jats:sec><jats:title>Conclusion</jats:title><jats:p>In selected cases, liver resection is possible post SIRT. As this can represent a potentially curative option, it is important to reconsider resection in the follow-up of patients undergoing SIRT. Post-operative complications are noted following major and extended liver resection. Therefore, further studies are needed to improve patient selection.</jats:p></jats:sec>