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Richter, Christian; Hohmann, Katharina F.; Toews, Sabrina; Mathieu, Daniel; Altincekic, Nadide; Bains, Jasleen Kaur; Binas, Oliver; Ceylan, Betül; Duchardt-Ferner, Elke; Ferner, Jan; Fürtig, Boris; Grün, J. Tassilo; Hengesbach, Martin; Hymon, Daniel; Jonker, Hendrik R. A.; Knezic, Bozana; Korn, Sophie M.; Landgraf, Tom; Löhr, Frank; Peter, Stephen A.; Pyper, Dennis J.; Qureshi, Nusrat S.; Schlundt, Andreas; Schnieders, Robbin; [...]

1H, 13C and 15N assignment of stem-loop SL1 from the 5'-UTR of SARS-CoV-2

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  • Medientyp: E-Artikel
  • Titel: 1H, 13C and 15N assignment of stem-loop SL1 from the 5'-UTR of SARS-CoV-2
  • Beteiligte: Richter, Christian; Hohmann, Katharina F.; Toews, Sabrina; Mathieu, Daniel; Altincekic, Nadide; Bains, Jasleen Kaur; Binas, Oliver; Ceylan, Betül; Duchardt-Ferner, Elke; Ferner, Jan; Fürtig, Boris; Grün, J. Tassilo; Hengesbach, Martin; Hymon, Daniel; Jonker, Hendrik R. A.; Knezic, Bozana; Korn, Sophie M.; Landgraf, Tom; Löhr, Frank; Peter, Stephen A.; Pyper, Dennis J.; Qureshi, Nusrat S.; Schlundt, Andreas; Schnieders, Robbin; [...]
  • Erschienen: Springer Science and Business Media LLC, 2021
  • Erschienen in: Biomolecular NMR Assignments
  • Sprache: Englisch
  • DOI: 10.1007/s12104-021-10047-2
  • ISSN: 1874-2718; 1874-270X
  • Schlagwörter: Biochemistry ; Structural Biology
  • Entstehung:
  • Anmerkungen:
  • Beschreibung: <jats:title>Abstract</jats:title><jats:p>The stem-loop (SL1) is the 5'-terminal structural element within the single-stranded SARS-CoV-2 RNA genome. It is formed by nucleotides 7–33 and consists of two short helical segments interrupted by an asymmetric internal loop. This architecture is conserved among Betacoronaviruses. SL1 is present in genomic SARS-CoV-2 RNA as well as in all subgenomic mRNA species produced by the virus during replication, thus representing a ubiquitous <jats:italic>cis</jats:italic>-regulatory RNA with potential functions at all stages of the viral life cycle. We present here the <jats:sup>1</jats:sup>H, <jats:sup>13</jats:sup>C and <jats:sup>15</jats:sup>N chemical shift assignment of the 29 nucleotides-RNA construct 5_SL1, which denotes the native 27mer SL1 stabilized by an additional terminal G-C base-pair.</jats:p>