Beschreibung:
<jats:p>Previous studies had shown that binding of TGF‐β to the small proteoglycan decorin results in its inactivation. Indeed, in osteosarcoma cells the addition of decorin prevented the TGF‐β1‐mediated up‐regulation of biglycan synthesis. However, the down‐regulation of proteoglycan‐100 remained unaltered. Even in the presence of a 100,000‐fold molar excess of decorin, TGF‐β1 was fully active in U937 monocytes with respect to the inhibition of cell proliferation. There was no inhibition of the TGF‐β‐mediated stimulation of the retraction of fibroblast‐populated collagen lattices. Thus, the formation of TGF‐β/decorin complexes leads to the neutralization of distinct effects only.</jats:p>