Beschreibung:
<jats:title>Abstract</jats:title><jats:sec id="S1352465822000662_as1"><jats:title>Background:</jats:title><jats:p>Cognitive behavioural therapy (CBT) and medication are widely accepted and useful interventions for individuals with depression. However, a gap remains in our current understanding of how CBT directly benefits adolescents with depression.</jats:p></jats:sec><jats:sec id="S1352465822000662_as2"><jats:title>Aims:</jats:title><jats:p>The purpose of this study was to examine the short- and long-term effectiveness of CBT only, CBT+Medication, or Medication alone in reducing the duration of major depressive episodes, lessening internalizing and externalizing symptoms and improving global functioning.</jats:p></jats:sec><jats:sec id="S1352465822000662_as3"><jats:title>Methods:</jats:title><jats:p>Data were extracted from 14 unique studies with a total of 35 comparisons. Network meta-analysis was conducted and <jats:italic>p</jats:italic>-scores, a measure of the extent of certainty that one treatment is better than another, were used to rank treatments.</jats:p></jats:sec><jats:sec id="S1352465822000662_as4"><jats:title>Results:</jats:title><jats:p>There was no significant difference between any two treatments for depression, nor internalizing or externalizing symptoms. For global functioning, CBT had significantly greater effect at the longest follow-up than CBT+Medication. CBT+Medication had the highest <jats:italic>p</jats:italic>-score for depression, short- and long-term effects, and internalizing and externalizing symptoms long-term effects. No indication of publication bias was found.</jats:p></jats:sec><jats:sec id="S1352465822000662_as5"><jats:title>Conclusions:</jats:title><jats:p>Neither modality, CBT nor medication, is superior for treating adolescent depression. However, CBT was superior in improving global functioning, which is essential for meeting developmental goals.</jats:p></jats:sec>