Discovery of (R)-6-Cyclopentyl-6-(2-(2,6-diethylpyridin-4-yl)ethyl)-3-((5,7-dimethyl-[1,2,4]triazolo[1,5-a]pyrimidin-2-yl)methyl)-4-hydroxy-5,6-dihydropyran-2-one (PF-00868554) as a Potent and Orally Available Hepatitis C Virus Polymerase Inhibitor

Medientyp: E-Artikel

Titel: Discovery of (R)-6-Cyclopentyl-6-(2-(2,6-diethylpyridin-4-yl)ethyl)-3-((5,7-dimethyl-[1,2,4]triazolo[1,5-a]pyrimidin-2-yl)methyl)-4-hydroxy-5,6-dihydropyran-2-one (PF-00868554) as a Potent and Orally Available Hepatitis C Virus Polymerase Inhibitor

Beteiligte: Li, Hui; Tatlock, John; Linton, Angelica; Gonzalez, Javier; Jewell, Tanya; Patel, Leena; Ludlum, Sarah; Drowns, Matthew; Rahavendran, Sadayappan V.; Skor, Heather; Hunter, Robert; Shi, Stephanie T.; Herlihy, Koleen J.; Parge, Hans; Hickey, Michael; Yu, Xiu; Chau, Fannie; Nonomiya, Jim; Lewis, Cristina

Erschienen: American Chemical Society (ACS), 2009

Sprache: Englisch

DOI: 10.1021/jm8014537

ISSN: 0022-2623; 1520-4804

Schlagwörter: Drug Discovery ; Molecular Medicine

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