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Medientyp:
E-Artikel
Titel:
Retinol‐binding Protein 4, Visceral Fat, and the Metabolic Syndrome: Effects of Weight Loss
Beteiligte:
Tschoner, Alexander;
Sturm, Wolfgang;
Engl, Julia;
Kaser, Susanne;
Laimer, Markus;
Laimer, Elisabeth;
Weiss, Helmut;
Patsch, Josef R.;
Ebenbichler, Christoph F.
Erschienen:
Wiley, 2008
Erschienen in:Obesity
Sprache:
Englisch
DOI:
10.1038/oby.2008.391
ISSN:
1930-7381;
1930-739X
Entstehung:
Anmerkungen:
Beschreibung:
<jats:p>Retinol‐binding protein 4 (RBP‐4) has been reported to be associated with visceral‐fat accumulation and parameters of the metabolic syndrome (MetS). In this study, we investigated the relationship between RBP‐4, visceral fat, and the MetS during pronounced weight loss after bariatric surgery. Thirty‐six subjects were examined before and 2 years after surgery. Abdominal‐fat distribution was determined by ultrasound, metabolic parameters, and serum RBP‐4 levels by standard methods. After surgery BMI decreased by 9.07 kg/m<jats:sup>2</jats:sup>, visceral‐fat diameter (VFD) decreased by 60.6%, and RBP‐4 serum levels by 16.6%. Change of RBP‐4 levels was associated with reductions of waist (<jats:italic>r</jats:italic> = 0.364, <jats:italic>P</jats:italic> = 0.037), waist‐to‐hip ratio (WHR) (<jats:italic>r</jats:italic> = 0.415, <jats:italic>P</jats:italic> = 0.016), and VFD (<jats:italic>r</jats:italic> = 0.425, <jats:italic>P</jats:italic> = 0.010). MetS, as defined by International Diabetes Federation (IDF), was present in 19 patients at baseline and in nine patients at follow‐up. Change in RBP‐4 levels was the best predictor for the diagnosis of MetS at follow‐up. In the subgroup without MetS at baseline, the decrease in RBP‐4 levels (–28.1% vs. −6.3%, <jats:italic>P</jats:italic> = 0.020) and reduction in VFD (–66.9% vs. −55.0%, <jats:italic>P</jats:italic> = 0.038) were significantly greater compared to the subgroup with MetS. We demonstrate a marked decrease of RBP‐4 levels after bariatric surgery, which correlates with reduction in visceral‐fat mass. Furthermore, the extent of changes in RBP‐4 levels differs according to the severity of the MetS.</jats:p>