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Peter, Katrin; Siska, Peter J.; Roider, Tobias; Matos, Carina; Bruns, Heiko; Renner, Kathrin; Singer, Katrin; Weber, Daniela; Güllstorf, Martina; Kröger, Nicolaus; Wolff, Daniel; Herr, Wolfgang; Ayuk, Francis; Holler, Ernst; Stark, Klaus; Heid, Iris M.; Kreutz, Marina

1,25-dihydroxyvitamin-D3 but not the clinically applied marker 25-hydroxyvitamin-D3 predicts survival after stem cell transplantation

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  • Medientyp: E-Artikel
  • Titel: 1,25-dihydroxyvitamin-D3 but not the clinically applied marker 25-hydroxyvitamin-D3 predicts survival after stem cell transplantation
  • Beteiligte: Peter, Katrin; Siska, Peter J.; Roider, Tobias; Matos, Carina; Bruns, Heiko; Renner, Kathrin; Singer, Katrin; Weber, Daniela; Güllstorf, Martina; Kröger, Nicolaus; Wolff, Daniel; Herr, Wolfgang; Ayuk, Francis; Holler, Ernst; Stark, Klaus; Heid, Iris M.; Kreutz, Marina
  • Erschienen: Springer Science and Business Media LLC, 2021
  • Erschienen in: Bone Marrow Transplantation
  • Sprache: Englisch
  • DOI: 10.1038/s41409-020-01031-w
  • ISSN: 0268-3369; 1476-5365
  • Schlagwörter: Transplantation ; Hematology
  • Entstehung:
  • Anmerkungen:
  • Beschreibung: <jats:title>Abstract</jats:title><jats:p>The serum level of 25-hydroxyvitamin-D3 is accepted as marker for a person’s vitamin D status but its role for the outcome of allogeneic hematopoietic stem cell transplantation (HSCT) is controversially discussed. The impact of 1,25-dihydroxyvitamin-D3 on HSCT outcome, however, has never been studied. In a discovery cohort of 143 HSCT patients we repeatedly (day −16 to 100) measured 1,25-dihydroxyvitamin-D3 and in comparison the well-established marker for serum vitamin D status 25-hydroxyvitamin-D3. Only lower 1,25-dihydroxyvitamin-D3 levels around HSCT (day −2 to 7, peritransplant) were significantly associated with higher 1-year treatment-related mortality (TRM) risk (Mann–Whitney U test, <jats:italic>P</jats:italic> = 0.001). This was confirmed by Cox-model regression without and with adjustment for baseline risk factors and severe acute Graft-versus-Host disease (aGvHD; unadjusted <jats:italic>P</jats:italic> = 0.001, adjusted <jats:italic>P</jats:italic> = 0.005). The optimal threshold for 1,25-dihydroxyvitamin-D3 to identify patients at high risk was 139.5 pM. Also in three replication cohorts consisting of altogether 365 patients 1,25-dihydroxyvitamin-D3 levels below 139.5 pM had a 3.3-fold increased risk of TRM independent of severe aGvHD compared to patients above 139.5 pM (Cox-model unadjusted <jats:italic>P</jats:italic> &lt; 0.0005, adjusted <jats:italic>P</jats:italic> = 0.001). Our data highlight peritransplant 1,25-dihydroxyvitamin-D3 levels but not the commonly monitored 25-hydroxyvitamin-D3 levels as potent predictor of 1-year TRM and suggest to monitor both vitamin D metabolites in HSCT patients.</jats:p>
  • Zugangsstatus: Freier Zugang