> Detailanzeige

Klein-Hessling, Stefan; Muhammad, Khalid; Klein, Matthias; Pusch, Tobias; Rudolf, Ronald; Flöter, Jessica; Qureischi, Musga; Beilhack, Andreas; Vaeth, Martin; Kummerow, Carsten; Backes, Christian; Schoppmeyer, Rouven; Hahn, Ulrike; Hoth, Markus; Bopp, Tobias; Berberich-Siebelt, Friederike; Patra, Amiya; Avots, Andris; Müller, Nora; Schulze, Almut; Serfling, Edgar

NFATc1 controls the cytotoxicity of CD8+ T cells

Literatur-
verwaltung

Zur
Merkliste

Lösche von
Merkliste

Per Whatsapp teilen

Schließen

Merkliste



Sie können Bookmarks mittels Listen verwalten, loggen Sie sich dafür bitte in Ihr SLUB Benutzerkonto ein.
  • Medientyp: E-Artikel
  • Titel: NFATc1 controls the cytotoxicity of CD8+ T cells
  • Beteiligte: Klein-Hessling, Stefan; Muhammad, Khalid; Klein, Matthias; Pusch, Tobias; Rudolf, Ronald; Flöter, Jessica; Qureischi, Musga; Beilhack, Andreas; Vaeth, Martin; Kummerow, Carsten; Backes, Christian; Schoppmeyer, Rouven; Hahn, Ulrike; Hoth, Markus; Bopp, Tobias; Berberich-Siebelt, Friederike; Patra, Amiya; Avots, Andris; Müller, Nora; Schulze, Almut; Serfling, Edgar
  • Erschienen: Springer Science and Business Media LLC, 2017
  • Erschienen in: Nature Communications
  • Sprache: Englisch
  • DOI: 10.1038/s41467-017-00612-6
  • ISSN: 2041-1723
  • Schlagwörter: General Physics and Astronomy ; General Biochemistry, Genetics and Molecular Biology ; General Chemistry ; Multidisciplinary
  • Entstehung:
  • Anmerkungen:
  • Beschreibung: <jats:title>Abstract</jats:title><jats:p>Cytotoxic T lymphocytes are effector CD8<jats:sup>+</jats:sup> T cells that eradicate infected and malignant cells. Here we show that the transcription factor NFATc1 controls the cytotoxicity of mouse cytotoxic T lymphocytes. Activation of <jats:italic>Nfatc1</jats:italic><jats:sup> <jats:italic>−/−</jats:italic> </jats:sup> cytotoxic T lymphocytes showed a defective cytoskeleton organization and recruitment of cytosolic organelles to immunological synapses. These cells have reduced cytotoxicity against tumor cells, and mice with NFATc1-deficient T cells are defective in controlling Listeria infection. Transcriptome analysis shows diminished RNA levels of numerous genes in <jats:italic>Nfatc1</jats:italic><jats:sup> <jats:italic>−/−</jats:italic> </jats:sup> CD8<jats:sup>+</jats:sup> T cells, including <jats:italic>Tbx21</jats:italic>, <jats:italic>Gzmb</jats:italic> and genes encoding cytokines and chemokines, and genes controlling glycolysis. <jats:italic>Nfatc1</jats:italic><jats:sup> <jats:italic>−/−</jats:italic> </jats:sup>, but not <jats:italic>Nfatc2</jats:italic><jats:sup> <jats:italic>−/−</jats:italic> </jats:sup> CD8<jats:sup>+</jats:sup> T cells have an impaired metabolic switch to glycolysis, which can be restored by IL-2. Genome-wide ChIP-seq shows that NFATc1 binds many genes that control cytotoxic T lymphocyte activity. Together these data indicate that NFATc1 is an important regulator of cytotoxic T lymphocyte effector functions.</jats:p>
  • Zugangsstatus: Freier Zugang