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Prelli Bozzo, Caterina; Nchioua, Rayhane; Volcic, Meta; Koepke, Lennart; Krüger, Jana; Schütz, Desiree; Heller, Sandra; Stürzel, Christina M.; Kmiec, Dorota; Conzelmann, Carina; Müller, Janis; Zech, Fabian; Braun, Elisabeth; Groß, Rüdiger; Wettstein, Lukas; Weil, Tatjana; Weiß, Johanna; Diofano, Federica; Rodríguez Alfonso, Armando A.; Wiese, Sebastian; Sauter, Daniel; Münch, Jan; Goffinet, Christine; Catanese, Alberto; [...]

IFITM proteins promote SARS-CoV-2 infection and are targets for virus inhibition in vitro

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  • Medientyp: E-Artikel
  • Titel: IFITM proteins promote SARS-CoV-2 infection and are targets for virus inhibition in vitro
  • Beteiligte: Prelli Bozzo, Caterina; Nchioua, Rayhane; Volcic, Meta; Koepke, Lennart; Krüger, Jana; Schütz, Desiree; Heller, Sandra; Stürzel, Christina M.; Kmiec, Dorota; Conzelmann, Carina; Müller, Janis; Zech, Fabian; Braun, Elisabeth; Groß, Rüdiger; Wettstein, Lukas; Weil, Tatjana; Weiß, Johanna; Diofano, Federica; Rodríguez Alfonso, Armando A.; Wiese, Sebastian; Sauter, Daniel; Münch, Jan; Goffinet, Christine; Catanese, Alberto; [...]
  • Erschienen: Springer Science and Business Media LLC, 2021
  • Erschienen in: Nature Communications
  • Sprache: Englisch
  • DOI: 10.1038/s41467-021-24817-y
  • ISSN: 2041-1723
  • Entstehung:
  • Anmerkungen:
  • Beschreibung: <jats:title>Abstract</jats:title><jats:p>Interferon-induced transmembrane proteins (IFITMs 1, 2 and 3) can restrict viral pathogens, but pro- and anti-viral activities have been reported for coronaviruses. Here, we show that artificial overexpression of IFITMs blocks SARS-CoV-2 infection. However, endogenous IFITM expression supports efficient infection of SARS-CoV-2 in human lung cells. Our results indicate that the SARS-CoV-2 Spike protein interacts with IFITMs and hijacks them for efficient viral infection. IFITM proteins were expressed and further induced by interferons in human lung, gut, heart and brain cells. IFITM-derived peptides and targeting antibodies inhibit SARS-CoV-2 entry and replication in human lung cells, cardiomyocytes and gut organoids. Our results show that IFITM proteins are cofactors for efficient SARS-CoV-2 infection of human cell types representing in vivo targets for viral transmission, dissemination and pathogenesis and are potential targets for therapeutic approaches.</jats:p>
  • Zugangsstatus: Freier Zugang