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Zunhammer, Matthias; Spisák, Tamás; Wager, Tor D.; Bingel, Ulrike; Atlas, Lauren; Benedetti, Fabrizio; Büchel, Christian; Choi, Jae Chan; Colloca, Luana; Duzzi, Davide; Eippert, Falk; Ellingsen, Dan-Mikael; Elsenbruch, Sigrid; Geuter, Stephan; Kaptchuk, Ted J.; Kessner, Simon S.; Kirsch, Irving; Kong, Jian; Lamm, Claus; Leknes, Siri; Lui, Fausta; Müllner-Huber, Alexa; Porro, Carlo A.; Rütgen, Markus; [...]

Meta-analysis of neural systems underlying placebo analgesia from individual participant fMRI data

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  • Medientyp: E-Artikel
  • Titel: Meta-analysis of neural systems underlying placebo analgesia from individual participant fMRI data
  • Beteiligte: Zunhammer, Matthias; Spisák, Tamás; Wager, Tor D.; Bingel, Ulrike; Atlas, Lauren; Benedetti, Fabrizio; Büchel, Christian; Choi, Jae Chan; Colloca, Luana; Duzzi, Davide; Eippert, Falk; Ellingsen, Dan-Mikael; Elsenbruch, Sigrid; Geuter, Stephan; Kaptchuk, Ted J.; Kessner, Simon S.; Kirsch, Irving; Kong, Jian; Lamm, Claus; Leknes, Siri; Lui, Fausta; Müllner-Huber, Alexa; Porro, Carlo A.; Rütgen, Markus; [...]
  • Erschienen: Springer Science and Business Media LLC, 2021
  • Erschienen in: Nature Communications
  • Sprache: Englisch
  • DOI: 10.1038/s41467-021-21179-3
  • ISSN: 2041-1723
  • Schlagwörter: General Physics and Astronomy ; General Biochemistry, Genetics and Molecular Biology ; General Chemistry ; Multidisciplinary
  • Entstehung:
  • Anmerkungen:
  • Beschreibung: <jats:title>Abstract</jats:title><jats:p>The brain systems underlying placebo analgesia are insufficiently understood. Here we performed a systematic, participant-level meta-analysis of experimental functional neuroimaging studies of evoked pain under stimulus-intensity-matched placebo and control conditions, encompassing 603 healthy participants from 20 (out of 28 eligible) studies. We find that placebo vs. control treatments induce small, widespread reductions in pain-related activity, particularly in regions belonging to ventral attention (including mid-insula) and somatomotor networks (including posterior insula). Behavioral placebo analgesia correlates with reduced pain-related activity in these networks and the thalamus, habenula, mid-cingulate, and supplementary motor area. Placebo-associated activity increases occur mainly in frontoparietal regions, with high between-study heterogeneity. We conclude that placebo treatments affect pain-related activity in multiple brain areas, which may reflect changes in nociception and/or other affective and decision-making processes surrounding pain. Between-study heterogeneity suggests that placebo analgesia is a multi-faceted phenomenon involving multiple cerebral mechanisms that differ across studies.</jats:p>
  • Zugangsstatus: Freier Zugang