> Detailanzeige

Pina-Camacho, Laura; Martinez, Kenia; Diaz-Caneja, Covadonga M.; Mezquida, Gisela; Cuesta, Manuel J.; Moreno, Carmen; Amoretti, Silvia; González-Pinto, Ana; Arango, Celso; Vieta, Eduard; Castro-Fornieles, Josefina; Lobo, Antonio; Fraguas, David; Bernardo, Miguel; Janssen, Joost; Parellada, Mara; Madero, Santiago; Gómez-Ramiro, Marta; Rodriguez-Toscano, Elisa; Santonja, Javier; Zorrilla, Iñaki; González-Ortega, Itxaso; Fayed, Nicolás; Santabárbara, Javier; [...]

Cortical thinning over two years after first-episode psychosis depends on age of onset

Literatur-
verwaltung

Zur
Merkliste

Lösche von
Merkliste

Per Whatsapp teilen

Schließen

Merkliste



Sie können Bookmarks mittels Listen verwalten, loggen Sie sich dafür bitte in Ihr SLUB Benutzerkonto ein.
  • Medientyp: E-Artikel
  • Titel: Cortical thinning over two years after first-episode psychosis depends on age of onset
  • Beteiligte: Pina-Camacho, Laura; Martinez, Kenia; Diaz-Caneja, Covadonga M.; Mezquida, Gisela; Cuesta, Manuel J.; Moreno, Carmen; Amoretti, Silvia; González-Pinto, Ana; Arango, Celso; Vieta, Eduard; Castro-Fornieles, Josefina; Lobo, Antonio; Fraguas, David; Bernardo, Miguel; Janssen, Joost; Parellada, Mara; Madero, Santiago; Gómez-Ramiro, Marta; Rodriguez-Toscano, Elisa; Santonja, Javier; Zorrilla, Iñaki; González-Ortega, Itxaso; Fayed, Nicolás; Santabárbara, Javier; [...]
  • Erschienen: Springer Science and Business Media LLC, 2022
  • Erschienen in: Schizophrenia
  • Sprache: Englisch
  • DOI: 10.1038/s41537-021-00196-7
  • ISSN: 2754-6993
  • Entstehung:
  • Anmerkungen:
  • Beschreibung: <jats:title>Abstract</jats:title><jats:p>First-episode psychosis (FEP) patients show structural brain abnormalities at the first episode. Whether the cortical changes that follow a FEP are progressive and whether age at onset modulates these changes remains unclear. This is a multicenter MRI study in a deeply phenotyped sample of 74 FEP patients with a wide age range at onset (15–35 years) and 64 neurotypical healthy controls (HC). All participants underwent two MRI scans with a 2-year follow-up interval. We computed the longitudinal percentage of change (PC) for cortical thickness (CT), surface area (CSA) and volume (CV) for frontal, temporal, parietal and occipital lobes. We used general linear models to assess group differences in PC as a function of age at FEP. We conducted post-hoc analyses for metrics where PC differed as a function of age at onset. We found a significant age-by-diagnosis interaction effect for PC of temporal lobe CT (<jats:italic>d</jats:italic> = 0.54; <jats:italic>p</jats:italic> = 002). In a post-hoc-analysis, adolescent-onset (≤19 y) FEP showed more severe longitudinal cortical thinning in the temporal lobe than adolescent HC. We did not find this difference in adult-onset FEP compared to adult HC. Our study suggests that, in individuals with psychosis, CT changes that follow the FEP are dependent on the age at first episode, with those with an earlier onset showing more pronounced cortical thinning in the temporal lobe.</jats:p>
  • Zugangsstatus: Freier Zugang